Bone Metastases | GRACE

Update on Denosumab for Prevention of SREs

July 10, 2009 - 4:13 pm

Back in April I reviewed the use of Aredia, Zometa, and denosumab for the prevention of skeletal-related events (SREs), in patients with cancer with bony metastases. SREs, defined as pain or fracture in a bone from cancer involvement, can result in the need for radiation, surgery, or other intervention, and consequently is damaging to [...]

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An Emerging Potential Therapy for Bone Health: Denosumab

April 16, 2009 - 6:11 pm

In my last post, we covered an introduction to bone metastases and the use of the class of drugs known as bisphosphonates as a current standard treatment. A new investigational approach is also being tested, known as denosumab (AMG-162), which is a different from the bisphosphonates. A monoclonal antibody, denosumab is designed to attach [...]

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Overview of Bone Metastases and Bisphosphonate Treatment

April 14, 2009 - 8:34 pm

A query was recently raised about the use of denosumab for the treatment of bony metastases from lung cancer. We’ll cover what is known about that newer agent for bone metastases, but first let’s set the stage with a general discussion of the topic and the management options we’ve generally pursued over the past few years.
To put [...]

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