Denosumab | GRACE :: Cancer 101

Update on Denosumab for Prevention of SREs

July 10, 2009 - 4:13 pm

Back in April I reviewed the use of Aredia, Zometa, and denosumab for the prevention of skeletal-related events (SREs), in patients with cancer with bony metastases. SREs, defined as pain or fracture in a bone from cancer involvement, can result in the need for radiation, surgery, or other intervention, and consequently is damaging to [...]

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An Emerging Potential Therapy for Bone Health: Denosumab

April 16, 2009 - 6:11 pm

In my last post, we covered an introduction to bone metastases and the use of the class of drugs known as bisphosphonates as a current standard treatment. A new investigational approach is also being tested, known as denosumab (AMG-162), which is a different from the bisphosphonates. A monoclonal antibody, denosumab is designed to attach [...]

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