Avastin – impact on repair and physical therapy

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This topic contains 2 replies, has 3 voices, and was last updated by Dr West Dr West 6 years, 1 month ago.

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May 10, 2012 at 1:10 am  #2068    


my wife recently completed her 10th chemo session (FOLFOX w/avastin) for metastatic colon cancer. She is now very weak and needs physical therpay to regain muscule strength… does avastin, which she will stay on after chemo ends, inhibiit the body’s ability to form muscle tissue?

Likewise, as she had significant liver involvement, much of which turned nectrotic during chemo, will liver regeneration be dramatically slowed by avastin?

May 10, 2012 at 6:37 pm  #2069    

Dr Quesnelle

Hi Peter,

While avastin inhibits angiogenesis, maintenance doses are usually low and I am not aware of any significant data on the preclinical end that avastin can specifically inhibit muscle generation or dramatically slow liver repair. Best wishes to you & your wife.


May 10, 2012 at 8:35 pm  #2070    
Dr West
Dr West

We are concerned about the body’s ability to heal from something like a surgery if Avastin (bevacizumab) is given within the first month or so, but I don’t believe there’s evidence in the clinical world about Avastin interfering with conditioning or liver regeneration. People sometimes describe achy muscles that I think may be related to the daily regeneration of muscle fibers, and it’s a reasonable idea that it could interfere with liver regeneration, but other than withholding it in the first weeks after surgery, I’m not aware of any actual data on the subject.

-Dr. West

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