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Videos from the 2014 Immunotherapy Patient Forum for the Treatment of Melanoma, Lung and Kidney Cancers 

Please note, the information presented below was accurate in October 2014, but progress in immunotherapy moves quickly. If you have questions about the information in these videos, please post them in the GRACE forum.
 

What is Immunotherapy and its Mechanisms of Action? - Part 1
What is Immunotherapy and its Mechanisms of Action? – Part 1
15:58
In Part 1 of 2 videos on this topic, Dr. Drew Pardoll from the Kimmel Cancer Center at Johns Hopkins explains what immunotherapy is and how it helps cancer patients live longer – many for five years or more.
 
What is Immunotherapy and its Mechanisms of Action - Part 2
What is Immunotherapy and its Mechanisms of Action? – Part 2
14:26
In Part 2 of 2 videos on this topic, Dr. Drew Pardoll from the Kimmel Cancer Center at Johns Hopkins explains what immunotherapy is and how it helps cancer patients live longer – many for five years or more.
 
History of Immunotherapy in Cancer - Part 1
History of Immunotherapy in Cancer – Part 1
12:36
In Part 1 of 2 videos on this topic, Dr. Matthew Hellmann from the Memorial Sloan Kettering Cancer Center discusses the century-long history of attempting to treat cancer with immunotherapy.
 
History of Immunotherapy in Cancer - Part 2
History of Immunotherapy in Cancer – Part 2
13:16
In Part 2 of 2 videos on this topic, Dr. Matthew Hellmann from the Memorial Sloan Kettering Cancer Center discusses the century-long history of attempting to treat cancer with immunotherapy.
 
How Immunotherapy is Administered - Part 1
How Immunotherapy is Administered – Part 1
11:49
In Part 1 of 2 videos on this topic, Dr. Jason Luke from the University of Chicago talks about the types of immunotherapy currently in use for melanoma, kidney cancer, and lung cancer and how they are given to patients.
 
How Immunotherapy is Administered - Part 2
How Immunotherapy is Administered – Part 2
9:43
In Part 2 of 2 videos on this topic, Dr. Jason Luke from the University of Chicago talks about the types of immunotherapy currently in use for melanoma, kidney cancer, and lung cancer and how they are given to patients.
 
Questions & Answers with Drs. Pardoll, Hellmann, and Luke; Moderated by Dr. West
Questions & Answers with Drs. Pardoll, Hellmann, and Luke; Moderated by Dr. West
16:59
Immunotherapy Forum Video #7: Drs. Pardoll, Hellman, and Luke sat for a moderated Q&A with Dr. Jack West.
 
Managing Immunotherapy Side Effects - Part 1
Managing Immunotherapy Side Effects – Part 1
16:06
Immunotherapy Forum Video #8: In Part 1 of 2 videos on this topic, oncology nurse Dr. Marianne Davies discusses the side effects that cancer patients who undergo immunotherapy treatment may experience and how to minimize them.
 
Managing Immunotherapy Side Effects - Part 2
Managing Immunotherapy Side Effects – Part 2
12:13
Immunotherapy Forum Video #9: In Part 2 of 2 videos on this topic, oncology nurse Dr. Marianne Davies discusses the side effects that cancer patients who undergo immunotherapy treatment may experience and how to minimize them.
 
The Patient Perspective
The Patient Perspective
7:47
“For all of the scholarly individuals here to give you the science, I’m here to give you the proof,” is how stage IV melanoma patient Rusty Cline kicks off the story of his remarkable response to immunotherapy.
 
Why is Immunotherapy More Effective in Some Cancers Than Others? - Part 1
Why is Immunotherapy More Effective in Some Cancers Than Others? – Part 1
10:59
In Part 1 of 2 videos on this topic, Dr. Michael Atkins explains why immunotherapy appears to be more effective in such cancers as melanoma, lymphomas, and kidney, lung, bladder, and head and neck cancers.
 
Why is Immunotherapy More Effective in Some Cancers Than Others? - Part 2
Why is Immunotherapy More Effective in Some Cancers Than Others? – Part 2
14:53
In Part 2 of 2 videos on this topic, Dr. Michael Atkins explains why immunotherapy appears to be more effective in such cancers as melanoma, lymphomas, and kidney, lung, bladder, and head and neck cancers.
 
Questions & Answers with Drs. Davies and Atkins, and patient Rusty Cline
Questions & Answers with Drs. Davies and Atkins, and patient Rusty Cline
20:35
Drs. Davies and Atkins, along with melanoma patient Rusty Cline, sat for a moderated Q&A with Dr. Jack West.
 
Immunotherapy for Melanoma, Pt. 1 - An Overview
Immunotherapy for Melanoma, Pt. 1: An Overview
13:06
In Part 1 of 2 videos on this topic, Dr. Suzanne Topalian provides a background on melanoma in the United States and how immunotherapy treatment for it has progressed over the past three decades.
 
Immunotherapy for Melanoma, Pt. 2 - Immune Checkpoints & the Drugs That Block Them
Immunotherapy for Melanoma, Pt. 2: Immune Checkpoints & the Drugs That Block Them
11:16
In Part 2 of 2 videos on this topic, Dr. Suzanne Topalian discusses the immunotherapy drugs that are currently approved for the treatment of melanoma as well as future treatments on the horizon.
 
Melanoma Immunotherapy, Pt. 1 - The End of the Beginning
Melanoma Immunotherapy, Pt. 1: The End of the Beginning
11:24
In Part 1 of 2 videos on this topic, Dr. Jedd Wolchok provides a history of one of the first immunotherapy drugs, Yervoy (ipilumumab), and the evidence that led to its approval.
 
Melanoma Immunotherapy, Pt. 2 - The End of the Beginning
Melanoma Immunotherapy, Pt. 2: The End of the Beginning
11:34
In Part 2 of 2 videos on this topic, Dr. Jedd Wolchok discusses side effects related to immunotherapy, combination therapies, and information about new immunotherapies currently being studied for treating melanoma.
 
Questions & Answers with Drs. Topalian and Wolchok about Immunotherapy for Melanoma
Questions & Answers with Drs. Topalian and Wolchok about Immunotherapy for Melanoma
16:14
Drs. Topalian and Wolchok sat for a moderated Q&A with Dr. Louise Perkins from the Melanoma Research Alliance following their presentations on immunotherapy for melanoma.
 
Kidney Cancer Immunotherapy: PD-1 Pathway Clinical Trials
Kidney Cancer Immunotherapy: PD-1 Pathway Clinical Trials
16:47
Dr. Lauren Harshman discusses treating kidney cancer with immunotherapy. In this video, she focuses on clinical trials studying PD-1 and PDL-1 agents.
 
Kidney Cancer Immunotherapy: CTLA-4 & Vaccine Clinical Trials
Kidney Cancer Immunotherapy: CTLA-4 & Vaccine Clinical Trials
11:02
Dr. Lauren Harshman talks about clinical trials studying the CTLA-4 pathway, as well as vaccines.
 
Kidney Cancer Immunotherapy: Reasons for Cautious Optimism
Kidney Cancer Immunotherapy: Reasons for Cautious Optimism
18:45
Dr. Sumanta (Monty) Pal reviews the past, present, and future of immunotherapy for kidney cancer and expresses concern about early study results of newer treatments.
 
Kidney Cancer Immunotherapy Q&A
Kidney Cancer Immunotherapy Q&A
9:52
Drs. Lauren Harshman and Sumanta (Monty) Pal answer questions from the audience following their presentations on immunotherapy for kidney cancer. Moderated by Dr. Marianne Davies.
 
What We Know About Immunotherapy Treatments for Lung Cancer
What We Know About Immunotherapy Treatments for Lung Cancer
19:05
Dr. Jared Weiss highlights what doctors know about immunotherapy treatments for lung cancer. His words: “The pace of progress that I expect over the next 3 to 5 years will shock even the most optimistic…”
 
Currently Enrolling Clinical Trials of Single Agent Immunotherapies for Patients with Lung Cancer
Currently Enrolling Clinical Trials of Single Agent Immunotherapies for Patients with Lung Cancer
12:04
In Part 1 of 2 videos, Dr. Matthew Hellmann provides an overview of clinical trials currently available to early and late stage lung cancer patients that study single agent immunotherapies (i.e. only one treatment is given).
 
Immunotherapy for Lung Cancer: Currently Enrolling Clinical Trials of Combination Therapies
Immunotherapy for Lung Cancer: Currently Enrolling Clinical Trials of Combination Therapies
11:36
In Part 2 of 2 videos, Dr. Matthew Hellmann discusses currently enrolling clinical trials for lung cancer patients that study combination therapies (meaning an immunotherapy drug plus another drug is given).
 
Lung Cancer Immunotherapy Q&A
Lung Cancer Immunotherapy Q&A
21:18
Drs. Jared Weiss and Matthew Hellmann answer questions from the audience following their presentations on immunotherapy for lung cancer. Moderated by Dr. Jack West.
 
Who Benefits from Immunotherapy?
Who Benefits from Immunotherapy?
18:41
Immunotherapies work well in some, but not in others. Who benefits, and why? Dr. Sumanta (Monty) Pal explains what doctors are learning.
 
The Right Time for Cancer Immunotherapy: Before or After Surgery?
The Right Time for Cancer Immunotherapy: Before or After Surgery?
13:18
Doctors are still weighing the pros and cons of giving a cancer patient immunotherapy before or after resection surgery. In part 1 of 2 videos, Dr. Jason Luke details those risks and benefits.
 
The Future of Cancer Immunotherapy: Combination Treatments
The Future of Cancer Immunotherapy: Combination Treatments
11:12
In part 2 of 2, Dr. Jason Luke discusses treating cancer with immunotherapy and another drug, such chemotherapy or targeted therapies, as well as what we know about biomarkers that predict if an immunotherapeutic will work.
 
Redefining Success and Failure in Cancer Immunotherapy Trials
Redefining Success and Failure in Cancer Immunotherapy Trials
14:41
Immunotherapy for cancer has rewritten the rules for what we consider a successful response to treatment. Some tumors grow before they regress. Dr. Jedd Wolchok discusses why a new measurement criteria was developed.
 

An Immunotherapy Primer for Patients 

The following posts were written by Dr. H. Jack West as part of a collaboration between GRACE and PVI, PeerView Institute for Medical Education; December 2014

What is Immunotherapy, and Why Pursue It? (An Immunotherapy Primer for Patients, Pt. 1)
Immunotherapy has rapidly emerged as one of the most transformative influences on cancer care since the detection of a specific target with matched molecular therapies for many cancers.

How Is Immunotherapy Administered? (An Immunotherapy Primer for Patients, Pt. 2)
Although the different types of immunotherapy, including vaccines, cytokines, and checkpoint blockade therapies, have many distinct features, they are all administered either into the skin or as intravenous (IV) infusion, despite the convenience and appeal of oral therapies to many people with cancer.

Which Cancers, and Which Patients? (An Immunotherapy Primer for Patients, Pt. 3)
It has been recognized for decades that some cancer types are more subject to immune-based treatments than others.

What Are the Potential Side Effects? (An Immunotherapy Primer for Patients, Pt. 4)
While immunotherapies are sometimes considered to be nontoxic or minimally toxic alternatives to standard treatments such as chemotherapy, it is more appropriate to recognize that they can be exceptionally well tolerated but can also be associated with a distinct constellation of potential immune-mediated side effects that range from trivial to serious and potentially life-threatening.


 


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