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Thalidomide in Lung Cancer: Answers from Korea

September 21, 2007 - 9:41 pm

To many outside of oncology, thalidomide is primarily known for causing severe birth defects in women who received it in the 1960s as a sedative and treatment for morning sickness. These birth defects, in which babies were born with no arms or legs but with hands and feet directly attached [...]

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Novel Agents for Lung Cancer: Proteasome Inhibition with Velcade (Bortezomib)

August 31, 2007 - 7:47 pm

Much of the focus on novel agents has been on strategies like inhibition of the epidermal growth factor receptor (EGFR) that can stimulate tumor growth, or anti-angiogenesis, blocking the tumor blood supply. But there are other, novel therapies that are also being tested in lung cancer as well. One of these is [...]

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Temozolomide (Temodar) for Brain Metastases

April 30, 2007 - 9:21 pm

Historically, chemotherapy has had a relatively minor role in the management of brain metastases. Although there is a rather low response rate in the brain from some standard lung cancer chemo regimens, we generally conclude that most of our chemo can’t be too effective in the brain because of the blood-brain barrier [...]

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