NOSH Aspirin

This topic contains 5 replies, has 5 voices, and was last updated by  Dr West 2 years, 8 months ago.

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March 13, 2012 at 3:54 am  #1893    

charvnc

I\’ve been reading news stories about NOSH aspirin – what are your thoughts on it ?

March 13, 2012 at 6:45 am  #1894    

Dr Quesnelle

Hi Charvnc,

NOSH-aspirin is a new formulation of aspirin that contains the compounds nitric oxide (NO) and hydrogen sulfide (SH). The idea behind this is that the NO protects the lining of your stomach and gastrointestinal tract from the adverse effect of daily aspirin use, and the SH has been shown by these authors to have some additional anti-cancer activity.

The chemopreventive effects of 75mg of daily aspirin use has been reported in The Lancet in 2010 in patients (particularly for the prevention of stomach cancer), but no clinical trials have been performed yet with NOSH-aspirin. There is evidence in cancer cells that nitric oxide and hydrogen sulfide may have some anti-cancer effects, but this also has not been tested in humans.

I think this research is very exciting, but the data that everyone is all “abuzz” over is only reported by one group. It is far from being widely tested among scientists, let alone in human patients. We’ll have to wait and see what happens when more people try to validate these results.

In the meantime, here is a great link to some more info on NOSH-aspirin:

http://www.sciencedaily.com/releases/2012/03/120308132812.htm

Hope that helps!

  • This reply was modified 2 years, 9 months ago by  Dr Quesnelle.
  • This reply was modified 2 years, 9 months ago by  Dr Quesnelle.
March 26, 2012 at 12:19 am  #1919    

certain spring

I wanted to link to some new work just published in the Lancet by Peter Rothwell from the University of Oxford. This suggests that aspirin can actually help prevent distant metastases in people who already have cancer:
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(12)60209-8/fulltext
http://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(12)70112-2/abstract
I quote: “This finding suggests that aspirin might help in treatment of some cancers and provides proof of principle for pharmacological intervention specifically to prevent distant metastasis.”
I’ve been quite impressed by the responsible reporting of this research here in the UK – the danger of gastrointestinal bleeding from aspirin use has been emphasised, and people have been urged to speak to their doctor before rushing for the aspirin pack. Obviously there are issues with conflicting medications and so on. But I would be interested to hear any views from the doctors here?


49-year-old non-smoker, dx stage IV NSCLC May 2010 (squamous tumour of the left lung with multiple brain metastases). Radiotherapy to chest and brain; progressed through two cycles carbo/gemcitabine. Repeated lung collapses; pneumonia in collapsed lung, Nov 2010; bronchial stent placed, Dec 2010. Declined second-line Taxotere. Mutation testing Feb 2011, surprise EGFR exon deletion 19. Started Tarceva (150mg), Feb 2011. Progression in liver and elsewhere, May 2013.

March 26, 2012 at 7:59 am  #1920    

catdander forum moderator

Does the nosh aspirin have any effects on the bruising that is found in some people using regular baby aspirin?


My husband, 53 @ dx of stage 3 squam nsclc R. pancoast tumor 8/09 caused destruction of 3 ribs, touching brachial plexus. 2 core and 1 VATS undx biopsies. Open thoracotomy for 1 positive biopsy (unresectable). Chemorads, 9/09. MRI by pancoast specialty surgeon 11/09 spine met found, stage IV, Rad to spine, Chemo changed from cis/etop to navelbine/carbo. 6 cycles total. Tarceva 2/10-11/10. 3cm tumor L lung, biopsy undx w/collapsed lung. Gemzar, 12/10 through 7/12. NED 3/12, stop tx 7/12. Remains NED as of 8/14.

March 26, 2012 at 9:01 am  #1921    

Dr Quesnelle

Hi Catdander,

NOSH-aspirin hasn’t been used in clinical trials yet so there is no word on side effects, or safety or efficacy, for that matter. This will likely be a few years down the pike.

Best,

Kelly

March 26, 2012 at 5:30 pm  #1922    

Dr West

I’m going to plan to write a post on this subject of aspirin (not NOSH-aspirin, specifically) and the very provocative work coming out of the UK. I think it’s very interesting and very arguably clinically significant, but I’ll have more to say in a proper post.

-Dr. West


Howard (Jack) West, MD
Medical Oncologist

Views expressed here represent my opinion, not those of GRACE or Swedish Cancer Institute. This information does not constitute medical advice and is intended to supplement and not replace medical information provided by your doctor.

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