GRACE :: Head/Neck Cancer

Late Stage Oropharynx Cancer, Treatment and Side Effects by Dr. Geoffrey Geiger

Weekly list of side-effects from radiotherapy treatmentDr. Geoffrey Geiger, University of Pennsylvania, outlines the course of radiotherapy treatment and side effects for head and neck cancer.

 

Late Stage Oropharynx Cancer, Treatment and Side Effects Audio Podcast

 

What you will hear in part 3

  • Medications
  • Side effects; and 
  • Side effect management

 

Glossary of terms you will hear in part 3

For other cancer-related definitions, visit the National Cancer Institute’s online glossary at cancer.gov/dictionary.

  • Chemotherapy – Treatment with drugs that kill cancer cells.
  • Lymph node – A rounded mass of lymphatic tissue that is surrounded by a capsule of connective tissue. Lymph nodes filter lymph (lymphatic fluid), and they store lymphocytes (white blood cells). They are located along lymphatic vessels. Also called lymph gland.
  • Lymphatic fluid – The clear fluid that travels through the lymphatic system and carries cells that help fight infections and other diseases. Also called lymph.
  • Radiation therapy/Radiotherapy – The use of high-energy radiation from x-rays, gamma rays, neutrons, protons, and other sources to kill cancer cells and shrink tumors. Radiation may come from a machine outside the body (external-beam radiation therapy), or it may come from radioactive material placed in the body near cancer cells (internal radiation therapy). Systemic radiation therapy uses a radioactive substance, such as a radiolabeled monoclonal antibody, that travels in the blood to tissues throughout the body.

 


Late Stage Oropharynx Cancer, Planning for External Beam Radiotherapy by Dr. Geoffrey Geiger

Graphic showing radiotherapy targeting planDr. Geoffrey Geiger, University of Pennsylvania, discusses the process of planning radiotherapy for head and neck cancer.

 

Late Stage Oropharynx Cancer, Planning for External Beam Radiotherapy Audio Podcast

 

What you will hear in part 2

  • What to expect during radiation treatment

 

Glossary of terms you will hear in part 2

For other cancer-related definitions, visit the National Cancer Institute’s online glossary at cancer.gov/dictionary.

  • Chemotherapy – Treatment with drugs that kill cancer cells.
  • CT scan – A procedure that uses a computer linked to an x-ray machine to make a series of detailed pictures of areas inside the body. The pictures are taken from different angles and are used to create 3-dimensional (3-D) views of tissues and organs. A dye may be injected into a vein or swallowed to help the tissues and organs show up more clearly. A CT scan may be used to help diagnose disease, plan treatment, or find out how well treatment is working. Also called CAT scan, computed tomography scan, computerized axial tomography scan, and computerized tomography.
  • External beam radiotherapy – Radiation that comes from a machine outside the body
  • MRI – A procedure in which radio waves and a powerful magnet linked to a computer are used to create detailed pictures of areas inside the body. These pictures can show the difference between normal and diseased tissue. MRI makes better images of organs and soft tissue than other scanning techniques, such as computed tomography (CT) or x-ray. MRI is especially useful for imaging the brain, the spine, the soft tissue of joints, and the inside of bones. Also called magnetic resonance imaging, NMRI, and nuclear magnetic resonance imaging
  • Oropharynx/Oropharyngeal cancer – Cancer that forms in tissues of the oropharynx (the part of the throat at the back of the mouth, including the soft palate, the base of the tongue, and the tonsils). Most oropharyngeal cancers are squamous cell carcinomas (cancer that begins in flat cells lining the oropharynx).
  • Parotid gland – The largest of the salivary glands, which make saliva and release it into the mouth. There are 2 parotid glands, one in front of and just below each ear.
  • PET scan – A procedure in which a small amount of radioactive glucose (sugar) is injected into a vein, and a scanner is used to make detailed, computerized pictures of areas inside the body where the glucose is taken up. Because cancer cells often take up more glucose than normal cells, the pictures can be used to find cancer cells in the body. Also called positron emission tomography scan.
  • Radiation therapy/Radiotherapy – The use of high-energy radiation from x-rays, gamma rays, neutrons, protons, and other sources to kill cancer cells and shrink tumors. Radiation may come from a machine outside the body (external-beam radiation therapy), or it may come from radioactive material placed in the body near cancer cells (internal radiation therapy). Systemic radiation therapy uses a radioactive substance, such as a radiolabeled monoclonal antibody, that travels in the blood to tissues throughout the body. 
  • Squamous cell carcinoma – Cancer of the head and neck that begins in squamous cells (thin, flat cells that form the surface of the skin, eyes, various internal organs, and the lining of hollow organs and ducts of some glands). Squamous cell carcinoma of the head and neck includes cancers of the nasal cavity, sinuses, lips, mouth, salivary glands, throat, and larynx (voice box). Most head and neck cancers are squamous cell carcinomas.

 


Late Stage Oropharynx Cancer, Introduction and Management by Dr. Geoffrey Geiger

Graphic of lymphatic areas in the neckDr. Geoffrey Geiger, University of Pennsylvania, provides an introduction to head and neck cancer and the human papilloma virus.

 

Late Stage Oropharynx Cancer, Introduction and Management Audio Podcast

 

What you will hear in part 1

  • Oropharynx cancer basics
  • Risk factors; and 
  • The role of HPV

 

Glossary of terms you will hear in part 1

For other cancer-related definitions, visit the National Cancer Institute’s online glossary at cancer.gov/dictionary.

  • Chemotherapy – Treatment with drugs that kill cancer cells.
  • Carcinogen – Any substance that causes cancer.
  • Cisplatin – A drug used to treat malignant head and neck cancer. Cisplatin contains the metal platinum. It kills cancer cells by damaging their DNA and stopping them from dividing.
  • Definitive treatment – The treatment plan for a disease or disorder that has been chosen as the best one for a patient after all other choices have been considered.
  • Human Papilloma Virus/HPV – A type of virus that can cause abnormal tissue growth (for example, warts) and other changes to cells. Infection for a long time with certain types of HPV can cause cervical cancer. HPV may also play a role in some other types of cancer, such as anal, vaginal, vulvar, penile, oropharyngeal, and squamous cell skin cancers. Also called human papillomavirus.
  • Lymph node – A rounded mass of lymphatic tissue that is surrounded by a capsule of connective tissue. Lymph nodes filter lymph (lymphatic fluid), and they store lymphocytes (white blood cells). They are located along lymphatic vessels. Also called lymph gland.
  • Multi-disciplinary – In medicine, a term used to describe a treatment planning approach or team that includes a number of doctors and other health care professionals who are experts in different specialties (disciplines). In cancer treatment, the primary disciplines are medical oncology (treatment with drugs), surgical oncology (treatment with surgery), and radiation oncology (treatment with radiation).
  • Oropharynx/Oropharyngeal cancer – Cancer that forms in tissues of the oropharynx (the part of the throat at the back of the mouth, including the soft palate, the base of the tongue, and the tonsils). Most oropharyngeal cancers are squamous cell carcinomas (cancer that begins in flat cells lining the oropharynx).
  • Premalignant cancer – A term used to describe a condition that may (or is likely to) become cancer. Also called precancerous.
  • Prophylactic – In medicine, something that prevents or protects.
  • Radiation therapy/Radiotherapy – The use of high-energy radiation from x-rays, gamma rays, neutrons, protons, and other sources to kill cancer cells and shrink tumors. Radiation may come from a machine outside the body (external-beam radiation therapy), or it may come from radioactive material placed in the body near cancer cells (internal radiation therapy). Systemic radiation therapy uses a radioactive substance, such as a radiolabeled monoclonal antibody, that travels in the blood to tissues throughout the body. 
  • Squamous cell carcinoma – Cancer of the head and neck that begins in squamous cells (thin, flat cells that form the surface of the skin, eyes, various internal organs, and the lining of hollow organs and ducts of some glands). Squamous cell carcinoma of the head and neck includes cancers of the nasal cavity, sinuses, lips, mouth, salivary glands, throat, and larynx (voice box). Most head and neck cancers are squamous cell carcinomas.

 


FREE PATIENT WEBINAR: Chemo & Radiation for Late Stage Oropharynx Cancer

headandneck-diagramFriday, March 7, 2014 8:00 PM – 9:30 PM EST

Register today.

Over 30,000 Americans are diagnosed with oropharynx cancer (cancer of the tonsils or base of the tongue) each year. Stage III and stage IV cancers are curable, with the most common treatment being chemotherapy and radiation at the same time. Some patients respond very well to this treatment, while others do not. What options do patients have? What are the side effects of treatment? What are some of the latest advances in treatment?

Join the Global Resource for Advancing Cancer Education (GRACE) and Drs. Geoffrey Gieger and Jared Weiss for a webinar as they discuss the treatment of late stage oropharynx cancer.

On the webinar you will hear:
•   What is involved in getting chemotherapy and radiation?
•   What happens during a radiation treatment?
•   What happens during a chemotherapy treatment?
•   What kinds of radiation and chemotherapy are available and what’s the difference between them?
•   What are the side effects of chemotherapy and radiation?
•   The role of HPV in oropharynx cancer cancer.

Registration is free.


Dr. Weiss on Caveats and Emerging Concepts on HPV in Head/Neck Cancer

The second of two parts of the webinar by Dr. Jared Weiss on HPV in head/neck cancer focuses on some caveats about the early conclusions we’ve reached about HPV, then follows with a discussion of several new research questions being addressed by emerging  clinical trials in this population.

Here are the video and audio versions of this podcast, along with the associated transcript and figures:

Weiss HPV Pt 2 SCCHN Caveats and New Concepts Audio Podcast

Weiss HPV Pt 2 SCCHN Caveats and New Concepts Transcript

Weiss HPV Pt 2 SCCHN Caveats and New Concepts Figures

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Dr. Weiss on the Importance of HPV in Head and Neck Cancer, Part 1

What is HPVDr. Jared Weiss, specialist in head/neck and lung cancer at the University of North Carolina-Chapel Hill, contributed another excellent presentation recently on a topic in head and neck cancer that is dramatically changing the field as oncologists learn more about it. The human papilloma virus, or HPV, has long been known to be a critical factor in cervical cancer and some other cancer settings, but it has only been in recent years that we have begun to truly appreciate the magnitude of its impact in head and neck cancer and its potential relevance in practical management of head/neck cancer.  

Here is the first part of Dr. Weiss’s two-part program on HPV, focusing initially on defining HPV and its potential significance.

Weiss HPV Pt 1 Audio Podcast

Weiss HPV Pt 1 Transcript

Weiss HPV Pt 1 Figures

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Dr. Weiss on Induction Chemotherapy for Head and Neck Cancer: New Concepts Moving Forward

The second part of Dr. Weiss’s webinar on induction therapy focused on some new approaches in induction therapy that attempt to improve upon the difficult balance of efficacy and tolerability that haven’t necessarily been achieved by the better studied regimens for head and neck cancer.  Here is his discussion of several new clinical trials that attempt to improve on that balance.

Below you can find the video and audio versions of the podcast, along with the transcript and figures for it.

Weiss Induction Therapy for HNSCC Pt 2 New Concepts Moving Fwd Audio Podcast

Weiss Induction Therapy for HNSCC Pt 2 New Concepts Moving Fwd Transcript

Weiss Induction Therapy for HNSCC Pt 2 New Concepts Moving Fwd Figures

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Dr. Jared Weiss on Induction Therapy for Head and Neck Cancer, Part 1: Defining the Challenges

What is induction therapyOur own Dr. Weiss was kind enough to do a couple of critically important programs on head and neck cancer for GRACE, which will significantly upgrade our offerings to this underserved and understudied patient population.  The first program he did was on induction, also known as neo-adjuvant or pre-operative, therapy for patients with head and neck cancer.  The first part of his presentation defined the problem, the potential value of induction therapy, and the challenges associated with delivering both effective and safe induction therapy.

Here are the video and audio versions of the podcast from part 1 of his program, along with the associated transcript and figures.

Weiss Induction Therapy for HNSCC Pt 1 Audio Podcast

Weiss Induction Therapy for HNSCC Pt 1 Transcript

Weiss Induction Therapy for HNSCC Pt 1 Figs

We’ll have the second half available here in just a few days.  Thanks so much to Dr. Weiss for doing this!


Q&A Session with Dr. Ezra Cohen on Adjuvant Therapy for Head/Neck Cancer

Following the great webinar by Dr. Ezra Cohen from the University of Chicago on adjuvant therapy for head and neck cancer, with a focus on systemic therapy, we had the chance to ask some questions. Here is the question and answer session following that webinar.

qa-with-dr-cohen-on-adjuvant-therapy-for-head-neck-cancer-audio-podcast

qa-with-dr-cohen-on-adjuvant-therapy-for-head-neck-cancer-transcript

qa-with-dr-cohen-on-adjuvant-therapy-for-head-neck-cancer-figures

This program was made possible through an educational grant from Eli Lilly, who had no input in its content. We thank them for their support.


Podcast by Dr. Ezra Cohen on Adjuvant Therapy for Head/Neck Cancer: A Focus on Chemotherapy

On May 12, Dr. Ezra Cohen joined us on GRACE for a webinar. Dr.Cohen is an associate professor at the University of Chicago where he specializes in medical oncology for patients with lung cancer and head and neck cancer. Dr. Cohen’s talk came the day after Dr. Lin explained the role of radiation after surgery for head and neck cancer. Dr. Lin explained to us why some patients benefit from radiation after surgery to reduce recurrence risk. In this webinar, Dr.Cohen expanded on this subject, explaining that some patients who benefit from radiation after surgery will have even lower recurrence rates when chemotherapy is given together with the radiation.

Here are the links to the audio and video podcasts, the transcript, and the figures for the program

dr-cohen-adjuvant-therapy-for-head-neck-ca-audio-podcast

dr-cohen-adjuvant-therapy-for-head-neck-ca-transcript

dr-cohen-adjuvant-therapy-for-head-neck-ca-figures

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