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PET Scans For Restaging After Induction Treatment for Stage IIIA NSCLC

February 2, 2007 - 8:15 pm

   Purists have considered mediastinoscopy, which is invasive staging of the mediastinum through a small incision just at the base of the neck to get down behind the sternum, or breastbone, to be the “gold standard” for determining whether lymph nodes in the mediastinum, or middle of the chest, is involved with a cancer.   The […]

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Lung Cancer Screening, Part II: The Downside

January 25, 2007 - 7:02 pm

   The topic of lung cancer screening is a very charged one, with most people, patients and physicians alike, having a strong opinion, either for or against.  This is also an area in which there can be suspicion that any argument against screening is due to a financial calculation in which saving people from lung […]

17 Comments

Lung Cancer Screening, Part I: The Arguments FOR CT Screening

January 23, 2007 - 7:00 pm

   The issue of CT screening for lung cancer is a big one, and to handle it properly I’m going to write about it in a few installments.  It’s also quite controversial, so today I’ll start with the reasons in favor of CT screening.  Just by means of background, I’ll start by saying that chest […]

4 Comments

Early Disease Control: More Predictive of Clinical Benefit than Response

January 14, 2007 - 12:08 pm

   In my last post, I described our evolving recognition in the lung cancer field that significant response as the threshold for clinical benefit is too high and that stable disease is likely a relative benefit as well.  An important trial presented by Dr. Lara at UC Davis at ASCO (our biggest cancer meeting) in June, 2006 (abstract here) highlighted not […]

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EGFR Mutations and Acquired Resistance After Responding

November 4, 2006 - 4:33 pm

Thus far, the vast majority of patients who have an initial response to EGFR tyrosine kinase inhibitors like Iressa and Tarceva will eventually become resistant to them. At this year’s ASCO, our huge annual US-based oncology conference, a report was made by the group at Memorial Sloan Kettering Cancer Center (Riely abstract here) on a […]

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Staging BAC: Not the Ideal System Yet

October 13, 2006 - 11:37 am

Right now we use the same conventional staging system for BAC as with other lung cancers. I don’t have a great alternative just yet. I can tell you that as the lead investigator on several BAC trials, there are huge differences in the natural history of their cancer, regardless of what our treatment does. For […]

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