Lung Cancer / Mesothelioma
The treatment of relapsed SCLC isn’t especially controversial, because this is an area where there aren’t enough breakthroughs. In someone fit enough to perform their own activities of daily living and getting out of the house, the main question is how long it has been since they completed their first line treatment. Although some […]
2 CommentsI go to many meetings in which cases are presented and medical oncologists provide their repsonses about how they’d be inclined to treat a patient. Although we bemoan the lack of much progress in managing small cell lung cancer, one of the effects of that is that there is pretty strong uniformity in how […]
2 CommentsIn my earliest introductory post about SCLC, I described the typical staging breakdown used clinically, which is essentially divided into limited disease SCLC (LD-SCLC), which is typically treated with chemo and chest radiation together, with curative intent, and extensive disease SCLC (ED-SCLC), which is typically treated with chemo alone and is not considered conventionally curable. But […]
0 CommentsHere’s a situation in which I learned something from the questions raised by people here online. A handful of people with extensive disease small cell lung cancer (ED-SCLC) in the last year or two have mentioned receiving radiation for areas of residual apparent disease after receiving initial chemotherapy. I had noted that I had never […]
0 Comments Last year, I had the occasion in two prior posts (here and here) to highlight a new agent called amrubicin that is being studied in relapsed SCLC. At an ASCO conference where most of the news in SCLC was disappointing, amrubin studies again appeared promising.
The first of these studies was reported by Dr. David Ettinger at […]
As described in my last post, one of the interesting points we’ve seen from the recent trial of maintenance alimta vs. placebo after first line chemo for advanced NSCLC is that alimta’s beneficial effects appear to be concentrated on the 2/3 of patients with non-squamous cancers, while the patients with squamous cell NSCLC did […]
0 CommentsGetting back to the issue of differences in side effects and efficacy of treatments based on differences in individuals and populations, let’s continue the story of how different populations appear to have significant differences in how the do on the same treatment regimen. In a recent prior post I described the SWOG-Japanese research collaboration […]
0 CommentsWhile the differences in anticipated clinical benefits from EGFR tyrosine kinase inhibitors like tarceva and iressa are well known (summarized in prior post), less well appreciated is the potentially significant differences in results with garden variety standard chemotherapy. These differences are likely to be very relevant as the US has a harder time getting […]
0 CommentsMember Wendy asked me about a drug called picoplatin that I had heard of but really didn’t have much familiarity with. This gave me an occasion to flesh out some background on this agent, which is being developed as a potential therapy for patients previously treated for lung cancer. Developed by Poniard Pharmaceuticals in South […]
3 CommentsThere’s been several discussions about the potential value of maintenance therapy after the initial chemotherapy for SCLC; I’ve discussed this subject in a prior post, in which I focused on chemo (prior post here) — while the results haven’t been strong enough to lead to a change in standard practice, at least one trial […]
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