GRACE :: Lung Cancer

Alice Shaw

Denise Brock

Targeted Therapies Patient Forum September 2017 Speaker Highlight – Alice Shaw MD, PhD

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***Speaker Highlights***

for full faculty bio’s, please visit our FACULTY page


 Learn about Alice Shaw, MD, PhD, Massachusetts General Hospital

 

Alice T. Shaw is the Director of the Center for Thoracic Cancers and the Paula O’Keeffe Endowed Chair of Thoracic Oncology at Massachusetts General Hospital.  She is also an Associate Professor of Medicine at Harvard Medical School. She received her A.B. in Biochemistry from Harvard and her M.D. and Ph.D. degrees from Harvard Medical School.  She did her residency in Internal Medicine at Massachusetts General Hospital and completed a fellowship in Hematology/Oncology at Dana-Farber/Massachusetts General Hospital.  She completed her postdoctoral work in the laboratory of Dr. Tyler Jacks at MIT.   

In addition to caring for patients with lung cancer, Dr. Shaw also performs clinical and translational research.  Her clinical research focuses on a variety of different molecularly-defined subsets of non-small cell lung cancer (NSCLC). Her translational research focuses on elucidating mechanisms of resistance to targeted therapies.  Based on her research, she has helped to develop numerous FDA-approved targeted therapies for patients with oncogene-driven NSCLC, and her current efforts focus on developing novel combinatorial strategies aimed at overcoming drug resistance.

Dr. Shaw has been awarded a number of research grants, including grants from the Damon Runyon Cancer Research Foundation, the Burroughs Wellcome Fund, the V Foundation for Cancer Research, Uniting Against Lung Cancer, the National Foundation for Cancer Research, SU2C/AACR/ACS, and the NIH/NCI.  In 2014 she was elected as a member to the American Society of Clinical Investigation.  She is a standing member of the FDA Oncologic Drugs Advisory Committee and she recently joined the LUNGevity Foundation Scientific Advisory Board. 


 

 

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Please feel free to offer comments and raise questions in our Discussion Forums.


Targeted Therapies in Lung Cancer Patient Forum

September 16, 2017

Presented by the Global Resource for Advancing Cancer Education in collaboration
with the Cleveland Clinic Cancer Center

See below for our growing list of topics and presenters!  

Register at cancerGRACE.org | Agenda is subject to change

8:30 – 10:00 am        The Many Faces of Progression
Dr. Nathan Pennell Cleveland Clinic Cancer Center The Role of Local Therapy
Dr. Shirish Gadgeel Karmanos Cancer Center, Wayne State University Biopsies & Re-biopsies
Dr. Karen Reckamp, City of Hope
10:30 – noon       
The Question of Clinical Trials
Dr. Alice Shaw Massachusetts General Hospital The Crossroads: Local Therapy, Chemo, Targeted Therapy, or Immunotherapy? 
Panel Discussion with Drs. Pennell, Gadgeel, Reckamp, and Shaw, and patients Matt Hiznay (ALK) and Sara Whitlock (RET). Moderator: Dr. H. (Jack) West

BREAKOUT SESSIONS

1:00 – 2:30 pm     
 
Presentations by Lung Cancer Sub-type
*Available treatment options 
*Acquired resistance: How do you pick your next treatment? 
ALK/ROS Dr. Alice Shaw, Dr. Shirish Gadgeel, & Matt Hiznay, ALK patient
EGFR Dr. Nathan Pennell, Dr. H. (Jack) West, & John Cherol, EGFR patient
MET/RET/BRAF Dr. Karen Reckamp, Dr. Vamsidhar Velcheti (Cleveland Clinic Cancer Center), & Sara Whitlock, RET patient

BREAKOUT SESSIONS

2:50 – 4:00 pm     
 
Managing the Costs of Cancer Care
James P. Stevenson, MD Cleveland Clinic Cancer Center
Patient to Patient Mentoring
Kathryn Sefcek, MHA 4th Angel Mentoring Program
Avoiding Fake News & Finding Trustworthy Cancer Info Online
Dr. H. (Jack) West Swedish Cancer Institute & Founder of cancerGRACE
Janet Freeman-Daily ROS1 patient, #LCSM Twitter Chat co-moderator, Cure Today contributor, Gray Connections blogger

 Please feel free to offer comments and raise questions in our Discussion Forums.

 GRACE would like to thank the following companies for their support of this forum:

B-I for web           
Guardant

 

 


GRACE Video

It’s Possible to Live WITH Cancer

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This November, GRACE Honors the Empowered Patient.November is Lung Cancer Awareness Month. To mark it this year, GRACE is celebrating the empowered lung cancer patient. In this video, Linnea Duff, a 10-year stage IV ALK+ lung cancer patient, shares her journey from stunned patient to empowered patient.

Watch, read, and then share your own stories of empowerment in our online forum. Your story may inspire others.


Dr West

Dr. Alice Shaw on Clinical Factors Associated with Molecular Markers

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I’m happy to bring you now the second part of the Santa Monica webinar, developed with the LUNGevity Foundation, on “Molecular Markers in Advanced NSCLC: Who to Test and What to Test For?“, in which I was joined by Drs. Charles Rudin (Johns Hopkins University in Balimore, MD), Alice Shaw (Massachusetts General Hospital in Boston, MA), David Spigel (Sarah Cannon Cancer Center in Nashville, TN), and Glen Gloss (University of Ottawa in Ontario, Canada).  

In this short podcast, Dr. Alice Shaw reviewed the frequencies of different molecular markers in advanced NSCLC as a function of patient sex, smoking status, race, and tumor histology.  This work is very interesting, of course, because if we only do molecular marker studies of people with an adenocarcinoma or never-smokers, we not only won’t ever find potentially relevant mutations in people with other histologies and those with a smoking history, but we won’t have any good idea of the probabilities of finding them either.

Here is the podcast in audio and video formats, as well as the transcript and figures.

Molecular Markers SM Pt 2 Shaw on Markers by Clin Factors Audio Podcast

Molecular Markers SM Pt 2 Shaw on Markers by Clin Factors Transcript

Molecular Markers SM Pt 2 Shaw on Markers by Clin Factors Figs

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Dr West

The ROS1 Mutation: A Target for a Small Population with Apparent Sensitivity to XALKORI

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After the last several posts have discussed our friend and lung cancer expert Dr. Ross Camidge, we’ll turn to the related topic of ROS mutations, which have been the subject of research by Dr. Ross Camidge (though apparently not named for him) and also researchers at Massachusetts General Hospital. This is a gene for a DNA repair protein, and the tyrosine kinase binding portion (the part that gets turned on to set off a cascade of downstream intracellular events) for ROS1 is very similar to that for ALK. In the lab, ALK inhibitors can also inhibit ROS1, and now the first few patients have been at the same centers that have done the initial work with XALKORI (crizotinib) — Massachusetts General Hospital, University of Colorado, University of California at Irvine, and now Peter MacCallum Cancer Centre in Melbourne, Australia — are also studying this agent in people with a ROS1 mutation. Apparently, the results with XALKORI in the few ROS1 mutation patients thus far are very encouraging, though this work hasn’t been published or presented yet in a large forum. Apparently Dr. Alice Shaw from Massachusetts General Hospital will be the lead author on a publication about to be published in the next week or so. I’ll share details when it’s available in the public domain.

How common is the mutation and who has it? Unfortunately, this group is so small that it makes the ALK positive population look big. It’s looking like about 1% of the lung cancer population, and these are again the patients who are never-smokers and have an adenocarcinoma, with pure bronchiololoalveolar carcinoma (BAC) also over-represented, younger patients, and perhaps a little more common in Asian than non-Asian patients. These are also patients who haven’t tested positive for EGFR, KRAS, or ALK, or other mutations being tested for by the Lung Cancer Mutation Consortium, for that matter.

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