Stereotactic Lung Radiotherapy (SBRT) vs. Wedge Resection for Stage I NSCLC

   The subject of stereotactic lung radiotherapy (SBRT) for cure of stage I disease has been extensively covered on GRACE with good cause: we may be witnessing a major change in how we treat early stage cancer. Multiple strategies for improved surveillance are being developed, and hopefully one or more will be successful, resulting in [...]

Dr. Le, Radiation Oncologist from Stanford, on Radiation Options for Early Stage NSCLC

Dr.  Quynh Le, radiation oncologist and Professor at Stanford University, was kind enough to participate in our NSCLC Patient Education Forum.  She spoke on the topic of emerging treatment options using radiation for early stage NSCLC.   The new work she’s describing on stereotactic body radiation therapy (SBRT) is looking promising enough that it’s being [...]

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Dr. Wakelee on the Highlights of Adjuvant Therapy for Early Stage NSCLC

I’m proud to say that many years ago I sent Dr. Heather Wakelee from Stanford a set of my slides on post-operative therapy for early stage NSCLC — we’ ve been friends since we were both getting started in our careers.
Flash forward several years, and now she’s among the national leaders in the field of [...]

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Dr. Ralph Aye, Thoracic Surgeon, on Surgery in Management of NSCLC

As the next installment of the podcast series from the GRACE NSCLC Patient Education Forum, I’m pleased to offer a presentation by the Chief of the Thoracic Oncology Division at Swedish Medical Center in Seattle — my own institution.  Dr. Aye has been at the center of the program from the beginning, and whatever success [...]

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PET/CT Scans in Staging to Reduce “Futile Thoracotomies”

Over the lasat decade, PET scans have become commonplace in the staging of NSCLC.  There’s an older post that reviews the concept of PET scans in providing metabolic imaging, as well as a podcast that provides a more complete discussion of PET scanning in oncology, with a focus on lung cancer.
A recent paper in the [...]

Interview with Dr. Sarita Dubey on Chemo for Early Stage NSCLC

Here’s an interview I did a few weeks before ASCO with Dr. Sarita Dubey, medical oncologist at the University of California at San Francisco.  This podcast covers a discussion we had about her views on the role of chemotherapy for patients with resected or resectable early stage NSCLC.

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MSH2 and Platinum Resistance in Early Stage NSCLC: It’s Not All ERCC1

In 2007 there was much excitement about the publication of a study by the researchers behind the landmark IALT adjuvant chemotherapy trial, which suggested that patients with early stage NSCLC could be divided into those who benefited greatly from cisplatin-based adjuvant chemotherapy and those who did not.  The marker that defined these patients was called [...]

Pre-Op vs. Post-Op Chemo Showdown: The NATCH Trial

Post-operative, or adjuvant, chemotherapy is a standard approach for higher risk patients with resected early stage NSCLC, based on several randomized trials that have been presented and published in the last few years that show a survival benefit from chemotherapy.   All of the trials that have shown a statistically significant survival benefit have given [...]

Risk/Benefit from Adjuvant Chemo for Early Stage NSCLC: Maturing Data Help Us Discriminate Likely Beneficiaries

Over the last 5 years, it’s become standard to consider and often recommend post-operative chemotherapy to patients with higher risk, early stage lung cancer in order to reduce the risk of it recurring and increase the cure rate. In that time, we’ve also seen that there are subgroups of patients who may be [...]

GRACEcast Audio Interview: Dr. Janessa Laskin on Adjuvant Chemotherapy

   Interview by medical oncologist Dr. Howard (Jack) West with fellow medical oncologist and lung cancer expert Dr. Janessa Laskin from the British Columbia Cancer Agency in Vancouver, BC, Canada on current standards and controversial topics in post-operative (adjuvant) chemotherapy for early stage, resected NSCLC.
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