GRACE :: Lung Cancer

Exon 21

Does Gilotrif Help EGFR Positive Lung Cancer Patients?

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An analysis of two large studies of EGFR lung cancer patients tried to determine if Gilotrif helped patients live longer.

Combined OS analysis: mutation categories


Gilotrif (Afatinib) Reports Survival Benefit for EGFR Mutation-Positive Advanced NSCLC: Is it a Superior EGFR Inhibitor?

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One of the high profile presentations in the lung cancer track at ASCO 2014 was from Dr. James Yang of a pooled analysis of the LUX-Lung 3 and LUX-Lung 6 trials, each comparing Gilotrif (afatinib) to standard chemotherapy as first line treatment of EGFR mutation-positive advanced NSCLC, which for the first time demonstrated an actual survival benefit not seen in similarly designed trials with Iressa (gefitinib) or Tarceva (erlotinib). We should expect to see a huge marketing campaign built on this result, implying that Gilotrif is now the leading choice of oral EGFR inhibitors that would be considered for EGFR mutation-positive patients. But is this a fair claim?

The LUX-Lung 3 trial compared Gilotrif to cisplatin/Alimta (pemetrexed) in a global trial, while LUX-Lung 6 compared Gilotrif to cisplatin/gemcitabine in an Asian trial, each with over 300 EGFR mutation-positive patients. Both showed a highly significant improvement in response rate and progression-free survival that largely reproduced the same results seen in several preceding trials with Iressa (gefitinib) or Tarceva (erlotinib) vs. other chemo regimens over the past few years.  However, all of the preceding trials have failed to demonstrate a difference in overall survival (OS) from the EGFR tyrosine kinase inhibitor (TKI).  This has been presumed to have been because the vast majority of patients receiving initial chemotherapy have crossed over to an EGFR TKI at progression, with the presumption that these patients then demonstrate the same kind of dramatic and long-lasting response that we hope to see in EGFR mutation-positive patients starting on an EGFR TKI as initial treatment. In other words, we might presume that it doesn’t matter if you receive an EGFR TKI as first or subsequent treatment if you have an EGFR mutation, as long as you get it, so this “crossover” effect should negate any survival benefit from an EGFR TKI given as first line therapy.

The LUX-Lung trials did not demonstrate a significant improvement as individual studies, and in fact, the LUX-Lung 6 trial didn’t even show an improvement in median OS for the Gilotrif arm over chemotherapy. Overall, when we look at the absolute results of the two trials, at least in terms of median OS, we see that they did very comparably to preceding trials with other EGFR TKIs — in fact, the best median OS was seen in a Japanese trial with Iressa.

Is OS superior to other EGFR TKIs

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Top 10 Key Presentations at ASCO 2014: Join Us for Discussion at Upcoming #LCSM Chat 5/22

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Top10ListEvery year, many of the most important developments in cancer care are presented at ASCO. This year, we’ve got what I think is a very important year in lung cancer, with several practice-changing results/. Impressively, this is a year in which the most important trials include some focusing on first line treatment of patients with an EGFR mutation, some on acquired resistance in EGFR mutation-positive patients, some work on MET as a target, a couple on patients with squamous NSCLC or general NSCLC that includes squamous and non-squamous NSCLC, one striking finding in stage III resected NSCLC, and even a couple of most immediately practice-changing results in small cell lung cancer.

I’ll clarify that, working within the limit of a top 10 list , I couldn’t include some notable but negative trials, particularly those for which we’ve already learned of their negativity in press releases. And while immunotherapies continue to demonstrate their promise, the presentations at ASCO this year really just reinforce what we’ve already seen.  Because they don’t break significant new ground, this isn’t a year when immunotherapy trials are in the top 10 — though I expect at leasat one or two among next year’s top 10 list.

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New FDA Indication for First Line Tarceva in EGFR Mutation-Positive NSCLC May Be Good for Roche but BAD for Patients: Here’s Why

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Earlier this week, the FDA approved the oral epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) Tarceva (erlotinib) for the approximately 10% of advanced NSCLC patients with an activating EGFR mutation in North America and Europe (approximately 30% in Asia).   While that’s generally a good thing, and it’s in keeping with the evidence very strongly supporting erlotinib or another EGFR TKI as the optimal systemic therapy for patients with an activating EGFR mutation, the indication was paired with a positive result on a specific mutation test marketed by Roche called cobas and used in the EURTAC trial of Tarceva vs. chemo that was conducted in Europe on patients with an activating EGFR mutation on the Roche test that was approved to be paired with the first line Tarceva indication.

I’m concerned that this development may well be detrimental for patients, even if it’s a shrewd move for Roche.  Why? Because there is already a clear consensus that EGFR TKI therapy is the preferred treatment for patients with an activating EGFR mutation, and the evidence supporting it is so overwhelmingly compelling that it’s uncommon to have erlotinib refused by payers as the treatment of choice in EGFR TKI-naive patients, even before the official FDA approval.  Moreover, over the past 9 years since activating EGFR mutations were first identified, a wide range of different tests to detect them have been used.  We know that the excellent responses with EGFR TKIs are seen primarily in patients with the more common exon 19 and exon 21 mutations, which are the ones specifically detected with the cobas test from Roche, but many other testing platforms can do this quite well and have been used for years and years now to identify patients who are great candidates for early EGFR TKI therapy.  

By linking the indication for first line Tarceva in EGFR mutation-positive patients with a positive result on the cobas test, Roche may well have enforced a monopoly on molecular testing, but there is no reason to think that their test is meaningfully better than many other options.  To me, this move seems as crass and transparently commercial at the expense of good science and care as seeking an FDA approval that erlotinib needs to be taken daily with a venti Starbucks latte if Starbucks had wrangled their way into a strategic partnership and got written into the EURTAC protocol.  My fear is that many people who have had EGFR mutation testing done by other reputable sources will now have their opportunity to receive first line Tarceva jeopardized based on the linked approval of the indication with the test.  Some people may require additional biopsies and incur treatment delays, increased risks, and added costs just because Roche finagled an opportunistic rider on the science.

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Are There Significant Differences Among EGFR Mutations?

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Since we’ve come to appreciate the presence of distinct activating EGFR mutations associated with a very high probability of responding to an oral EGFR inhibitor, the question has emerged about whether there are significant differences in outcomes between the two most common ones, which are a deletion in exon 19 and a “point mutation” in exon 21. Some retrospective work in smaller aggregated series has suggested that patients with an exon 19 deletion tend to do best, but other work has suggested no difference between these two most common mutations. The recently reported trio of prospective trials of patients with an EGFR mutation receiving first line chemo or an EGFR inhibitor provide a good opportunity to evaluate this question.

The studies are actually pretty consistent in conveying that there is a modest trend toward the most favorable progression-free survival (PFS) in people with an exon 19 vs. an exon 21 mutation, but the differences aren’t great. Here are the PFS curves directly comparing the two main types of mutations in the Japanese trials with Iressa (gefitinib):

pfs-by-type-of-egfr-mutation (Click on image to enlarge)

So while the curve for exon 19 deletion is on top by a small margin, both activating mutations appear to follow a very similar trajectory overall, with no significant difference.

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