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Leora Horn

GRACE Video

Panel Q&A Session on ALK+ and ROS1 Acquired Resistance with Drs. Horn and Owonikoko

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Janet Daily-Freeman moderates a question & answer session with Drs. Leora Horn and Taofeek Owonikoko on issues of acquired resistance to targeted therapies for ALK+ and ROS1 patients.

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GRACE Video

The Blood/Brain Barrier for ALK Patients

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The brain is a common site of disease in patients with ALK+ lung cancer. In this video, Dr. Horn illustrates the line-up of ALK+ treatments and how they work breaking through the blood/brain barrier.

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GRACE Video

Panel Q&A Session on Acquired Resistance with Drs. Riely & Horn

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Dr. West moderates a question & answer session with Drs. Leora Horn and Greg Riely on issues of acquired resistance to targeted therapies for patients with advanced NSCLC that harbors a driver mutation.

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GRACE Video

Repeat Biopsies and Emerging Technologies for Plasma Sampling of Mutations Seen with Acquired Resistance

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Dr. Leora Horn of Vanderbilt University reviews the rapidly evolving issue and growing value of repeat biopsies, including plasma sampling as a “liquid biopsy” option, in the setting of acquired resistance to a driver mutation in advanced NSCLC.

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GRACE Video

How Important is the Impact of Smoking Cessation on Survival?

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Drs. Ben Solomon, Leora Horn, & Jack West review impressive data demonstrating a striking survival improvement from successful efforts at smoking cessation among smokers undergoing lung cancer CT screening.

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Transcript

Dr. West:  Finally, there’s a fair bit — we cover a lot of ground at the World Conference on Lung Cancer, and one of the topics that I think is good to have gotten airplay is smoking cessation, and tobacco interests and policy. I was surprised, and it was sobering to see a presentation at the Presidential Symposium that suggested that smoking cessation efforts, in the process of lung cancer screening, makes a bigger interest — has a bigger impact on patient survival, not necessarily from lung cancer, but potentially from cardiovascular issues, than picking up lung cancer. Were there things about the smoking cessation discussions during this meeting that had an impact for you, or that you found particularly surprising?

Dr. Solomon:  I’m not surprised with those findings, I think smoking has a huge range of detrimental health effects, even outside lung cancer — other types of cancer, as you pointed out, cardiovascular disease as well, and I think it’s important to have strong smoking cessation measures, both at the levels of doctors and patients, but also as a society, and at a governmental level. In Australia, we’ve recently introduced plain paper packaging of cigarettes, so instead of having very attractive, different colored cigarette boxes, the government has chosen that the nastiest shade of green, sort of a puke-colored, green-brown color, to wrap cigarette packets in now. Tobacco companies are taking the government to court because they know that it will impact on sales, but I think those sorts of measures together with, as unpopular as it may be, taxes on tobacco, are things that have real impacts on smoking rates in the population, and in young people.

Dr. West:  Yeah, absolutely. It turns out the biggest impact you can have is raising taxes, especially in young smokers. Your thoughts — anything to add?

Dr. Horn:  So, I think what Australia is doing is incredible, and I remember hearing about it at the last meeting. You know, the study that they presented with smoking cessation screening — the problem is, most patients who are being screened are over age 55, so they’ve been smoking for thirty years. And so, you know, the more that we can do to stop young people from ever starting is really going to be the key to reducing smoking-related cancers.

Dr. West:  Thank you so much for joining me.

Dr. Solomon: Thanks, Jack.

Dr. Horn: Thanks, Jack!


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