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Hypertrophic Pulmonary Osteoarthropathy (HPOA): An Unusual But Distinctive Complication of Lung Cancer

February 10, 2009 - 7:17 pm

Although it’s uncommon, hypertrophic osteoarthropahy, or HPOA, is an odd and therefore memorable syndrome that can be a side effect of lung cancer. It features an abnormal proliferation of skin and bone tissue, primarily in the hands and feet. Patients can develop clubbing, which is most commonly associated with NSCLC (up to 1/3 of patients) [...]

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The Subtleties of Progressive Disease: Why Some Oncologists Continue EGFR Inhibitors (or Other Agents) after Progression

February 7, 2009 - 3:17 pm

   One of the basic concepts of oncology is that you treat patients with different drugs once they’ve shown progression on a treatment, rather than continue that a patient has presumably become resistant to.  However, there are some exceptions to this: many or most women with breast cancer continue the antibody herceptin (trastuzumab) even after progression, adding [...]

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Clinical Factors of Prognosis in Surgical Series: A Focus on Smoking Status

January 27, 2009 - 10:52 pm

   In my last post I wrote about the prognostic value of molecular markers like EGFR and K-Ras that have generally been studied in patients with advanced NSCLC and treated with EGFR inhibitors, but these studies looked at prognosis in patients with early stage NSCLC who underwent surgery.  These studies also provided some interesting results [...]

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Lung Cancer Advocacy Summit, by the National Lung Cancer Partnership

January 14, 2009 - 9:24 pm

   Are you passionate about raising awareness of lung cancer but aren’t entirely sure how to do it? Or are you already an established lung cancer advocate but want to gain more tools and network with others who share your vision?
 
   Then apply to attend the National Lung Cancer Partnership’s 2nd Lung Cancer Advocacy Summit: Acquiring [...]

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Selection Bias, Eligibility Criteria, and Interpreting Trial Results (or, a little cynicism can be a good thing)

November 22, 2008 - 4:02 pm

  My kids are right in the middle of that time when they watch SpongeBob and see commercials for toys, cereals, and music, nearly every one is puncuated at the end with, “Daddy, can we get that?  I want that.”   There comes a time in everyone’s life, hopefully early on, when we learn that we won’t actually find [...]

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Management Options for SVC Syndrome

October 27, 2008 - 7:54 pm

   As I introduced in my last post, the superior vena cava SVC syndrome occurs in about 2-4% of lung cancer cases, and lung cancer is the leading reason for it.  One of the most important factors in managing it is to determine, usually with CT imaging, the cause of the SVC syndrome — generally whether [...]

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The Troubling Symptom of Bronchorrhea in BAC

October 10, 2008 - 6:03 pm

Warning: this symptom can be a little gross, so the delicate flowers out there should skip this post.
One of the more unusual but quite vexxing symptoms we sometimes see in lung cancer is called bronchorrhea, which is the copious production of watery sputum, specifically at least 100 ml per day. [...]

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The Timeliness Factor: Duration of Work-Up for Lung Cancer

September 12, 2008 - 3:54 pm

   One issue that everyone with lung cancer faces, but that we haven’t covered before, is the duration of a lung cancer work-up.  I’ve worked in a range of treatment settings and see patients for second opinions who come from very different backgrounds and receive their work-ups through completely different medical systems.  In that process, [...]

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What is the Genetic Component of Lung Cancer?

August 29, 2008 - 12:25 pm

   My name is Robert Resta, and I’m a certified genetic counselor working at the Hereditary Cancer Clinic at Swedish Cancer Institute in Seattle.  Dr. West asked me if I might provide a few general comments about the genetic contribution of lung cancer. 
   In truth, this is a complicated question. There is little doubt that [...]

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Breath Test for Detecting Lung Cancer Under Study, Looking Promising

August 17, 2008 - 9:05 pm

   Some members had previously asked about a breath test to detect lung cancer, and at the time I was not familiar with this work.  But research has been ongoing with a new test designed by Menssana Research to detect lung cancer (LC) by noting a pattern of volatile organic compounds (VOCs), essentially chemicals in [...]

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