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Denise Brock

Lung Cancer Video Library – Spanish Language: Video #18 Acquired Resistance to Targeted Therapies: Biology and Different Clinical Patterns

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For our 18th video in the GRACE Spanish Lung Cancer Library, Dr. Brian Hunis, Medical Director, Head and Neck Cancer Program, Memorial Cancer Institute, Miami, Florida, joined GRACE to discuss the basics of Lung Cancer for Spanish-speaking patients and caregivers.  In this video Dr. Hunis addresses acquired resistance to targeted therapies: biology and different clinical patterns.


 

 

 

 


 

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TRANSCRIPTS – Spanish and English
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Resistencia adquirida a las terapias dirigidas: Biología y diferentes patrones clínicos.

Lamentablemente inclusive en pacientes que tienen la translocación de ALK, eventualmente los pacientes van a desarrollar una resistencia adquirida, por lo cual la medicación con crizotinib no va a funcionar mas.

Por lo general, estos son pacientes que van a tener un prelapso o una recaída en sistema nervioso central o pulmón. Esos son pacientes a los cuales que uno va a considerar terapia de segunda línea o cambiar a quimioterapia.


Acquired resistance to targeted therapies: biology and different clinical patterns.

Unfortunately, even patients with ALK translocation will eventually develop an acquired resistance, resulting in crisotinib not working anymore.

In general, these patients will have a relapse or re-fall in the central nervous system or lung. In these patients, we will consider a second line therapy or change to chemotherapy.


Denise Brock

Lung Cancer Video Library – Spanish Language: Video #17 First Line Therapy for NSCLC Patients That Have Anaplastic Lymphoma Kinase (ALK) Positive

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GRACE Cancer Video Library - Lung

 

For our 17th video in the GRACE Spanish Lung Cancer Library, Dr. Brian Hunis, Medical Director, Head and Neck Cancer Program, Memorial Cancer Institute, Miami, Florida, joined GRACE to discuss the basics of Lung Cancer for Spanish-speaking patients and caregivers.  In this video Dr. Hunis speaks about first line therapy for non-small cell lung cancer patients that have anaplastic lymphoma kinase (ALK) positive.


 

 

 

 


 

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TRANSCRIPTS – Spanish and English
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Terapia de primera línea para pacientes con cáncer pulmonar de células no pequeñas que presentan la cinasa de linfoma anaplásico (CLA) positiva.

En los pacientes en los cuales uno describe que el adenocarcinoma de pulmón de células no pequeñas tiene la translocación del gen ALK, hay terapia dirigida que atacan exclusivamente a las células que expresan esa mutación. Por lo cual los efectos adversos, la toxicidad y las respuestas son muchísimo mejores.

La primera terapia para pacientes con translocación en ALK que se ha usado en el mundo es con crisotinib. Crisotinib es una píldora que se toma diariamente, es bien tolerada y con efectos muy positivos.


First line therapy for non-small cell lung cancer patients that have the anaplastic lymphoma kinase positive.

In patients that have adenocarcinoma of non-small cells and also have the ALK gene translocation, there is a targeted treatment that only attacks the cell that express this mutation. So, the side effects, toxicity and the response are better.

The first therapy for patients with the ALK translocation that has been used in the world is with crisotinib. Crisotinib is a pill that is taken daily, is well tolerated and with very positive effects.


Denise Brock

Lung Cancer Video Library – Spanish Language: Video #16 ALK Rearrangements: What Are They and Which Patients Have Them?

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GRACE Cancer Video Library - Lung

 

For our 16th video in the GRACE Spanish Lung Cancer Library, Dr. Brian Hunis, Medical Director, Head and Neck Cancer Program, Memorial Cancer Institute, Miami, Florida, joined GRACE to discuss the basics of Lung Cancer for Spanish-speaking patients and caregivers.  In this video Dr. Hunis speaks about ALK rearrangements, what they are and who has them.  


 

 

 

 


 

How Did You Like This Video?

Please feel free to offer comments and raise questions in our Discussion Forums.


 

TRANSCRIPTS – Spanish and English
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Reacomodos de la Cinasa de Linfoma Anaplásico (CLA): ¿Qué Son? Y ¿Qué Pacientes la Tienen?

El cancer de pulmón de células no pequeñas ha demostrado tener mutaciones genéticas que hacen que ese cancer se pueda desarrollar y crezca. Una de esas mutaciones presente en menos del 10% de los pacientes es la mutación o translocación del gen ALK.

Es mutación o translocación permite que una proteína oncogénica se desarrolle, con lo cual los pacientes están predispuestos a desarrollar cancer de pulmón de células no pequeñas.

Por lo general, esos son pacientes no fumadores, de sexo femenino o con una historia remota de consumo de tabaco de forma remota o muy limitada.


Rearrangements of the Anaplastic Kinase Lymphoma (ALK): What Are They? And, What Patients Have Them?

Non-small cell lung cancer has proved to have many mutations that make the cancer develop and grow. One of these mutations is in less than 10% of them and it’s the mutation or translocation of the ALK gene.

This mutation or translocation allows an oncogenic protein to develop, so these patients will be predisposed to develop non-small cell lung cancer.

In general, these are non-smokers, feminine patients or with a history of limited tobacco consumption.


Denise Brock

Lung Cancer Video Library – Spanish Language: Video #15 Treating Later Stage Small Cell Lung Cancer

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GRACE Cancer Video Library - Lung

 

For our 15th video in the GRACE Spanish Lung Cancer Library, Dr. Brian Hunis, Medical Director, Head and Neck Cancer Program, Memorial Cancer Institute, Miami, Florida, joined GRACE to discuss the basics of Lung Cancer for Spanish-speaking patients and caregivers.  In this video Dr. Hunis speaks about treating later stage small cell lung cancer.  


 

 

 

 


 

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TRANSCRIPTS – Spanish and English
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Tratamiento Para el Cáncer de Pulmón de Células Pequeñas en Estadio Avanzado

El tratamiento de cáncer de pulmón en células pequeñas de estadio extensivo es muy distinto al de células pequeñas de estadio temprano. La forma más distinta de tratarlo, es porque los pacientes, en general, no reciben quimioterapia y radioterapia al mismo tiempo en forma concurrente. Se les trata con quimioterapia de forma paliativa y la radioterapia se reserva también de forma paliativa, por ejemplo, si son pacientes que tienen metástasis óseas con dolor o si son pacientes que tienen metástasis en el sistema nervioso central. En pacientes que no tienen enfermedad en sistema nervioso central también se recomienda la radiación profiláctica del cráneo.


Treatment for Small Cell Lung Cancer in Advanced Stage

The treatment for small cell lung cancer in advanced stage is very different than the one used in early stage. The biggest difference, in general, is that these patients don’t receive chemotherapy and radiotherapy at the same time. They are treated with palliative chemotherapy and radiotherapy is saved for palliative cases, like for patients with bone metastasis that have pain or for patients with central nervous system metastasis. In patients that do not have the disease in the central nervous system, they are advised to take prophylactic cranium radiation.


Denise Brock

Lung Cancer Video Library – Spanish Language: Video #14 Treating Early Stage Small Cell Lung Cancer

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GRACE Cancer Video Library - Lung

 

For our 14th video in the GRACE Spanish Lung Cancer Library, Dr. Brian Hunis, Medical Director, Head and Neck Cancer Program, Memorial Cancer Institute, Miami, Florida, joined GRACE to discuss the basics of Lung Cancer for Spanish-speaking patients and caregivers.  In this video Dr. Hunis speaks about treating early stage small cell lung cancer.  


 

 

 

 


 

How Did You Like This Video?

Please feel free to offer comments and raise questions in our Discussion Forums.


 

TRANSCRIPTS – Spanish and English
download transcripts

Tratamiento para el Cáncer de Pulmón de Células Pequeñas en Estadio Temprano

El tratamiento de cáncer de pulmón de células pequeñas en estadios limitados al pulmón, probablemente al mediastino, y no se ha esparcido a ninguna parte del cuerpo, está hecho con fines curativos. Por lo cual uno hace todo lo posible para tratar de eliminar ese tumor. Por lo general, rara vez esos tumores se operan y en cambio se tratan con una combinación de quimioterapia y de radioterapia. Se hacen quimioterapia en conjunto con radioterapia. Una vez que la radioterapia se completa, por lo general un mes y medio después, se hace quimioterapia en consolidación.

Hace unos años había un estudio muy grande que demostró también que en pacientes que terminaron su tratamiento de quimioterapia-radioterapia y que no han tenido ningún tipo de evidencia de enfermedad en estudios de seguimiento o de pesquisa, esos pacientes son buenos candidatos para hacer radioterapia al cerebro, inclusive en ausencia de enfermedad, de forma profiláctica y eso tiene una disminución hasta del 30% de riesgo de enfermedad metastásico en el sistema nervioso central.


Treatment for Small Cell Lung Cancer in Early Stage

The treatment for small cell lung cancer in early stage that is limited to the lung, probably to the mediastinum and hasn’t gone into other parts of the body, its done with healing effects. So, we do everything that is possible in trying to eliminate that tumor. In general, these tumors are not surgically removed because they are treated with a combination of chemotherapy and immunotherapy. Once the radiotherapy is completed, in about a month and a half later, we do consolidation chemotherapy.

Many years ago, a big clinical trial proved that in patients that finish their chemotherapy-radiotherapy treatment and have not had evidence of disease in the inquest studies, will be good candidates for brain chemotherapy. Even in the absence of disease, as a prophylactic method, this treatment will reduce in 30% the risk of metastatic disease in the central nervous system.


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