GRACE :: Lung Cancer

stage 3

Denise Brock

Lung Cancer Video Library – Spanish Language: Video #44 Treatment of Stage III Unresectable Non-Small Cell Lung Cancer

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GRACE Cancer Video Library - Lung

 

We are pleased to continue this series of informational videos for our Spanish speaking community.  GRACE is pleased to welcome Dr. Rafael Santana-Davila, Assistant Professor with the University of Washington School of Medicine and Seattle Cancer Care Alliance.  In this 44th video for the Spanish lung cancer video library, Dr. Santana-Davila joined GRACE to discuss the treatment of stage 3 unresectable non-small cell lung cancer.


 

 

 

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TRANSCRIPTS – Spanish and English
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Tratamiento de Cancer de Pulmón de Células no Pequeñas en Estadio Tres no Resecable

Treatment of Stage III Nonresectable Non-Small Cell Lung Cancer

 

Rafael Santana-Davila, MD
Assistant Professor of Medicine
University of Washington Seattle Cancer Care Alliance
Seattle, Washington

 

Spanish TRANSCRIPT

Cuando el paciente se encuentra en estadio tres y no es candidato a cirugía porque el cancer está en varios ganglios del mediastino o por otras razones, lo que hacemos es quimioterapia con radiación al mismo tiempo. La radiación se da todos los días por cuatro a seis semanas y la quimioterapia dependiendo de qué régimen se escoge puede ser una vez por semana o dos ciclos de quimioterapia durante la radiación.

Para saber cuál quimioterapia es mejor es un poco controversial, pero depende mucho de la plática que se tiene con el paciente para conocer el tiempo que se tiene, los beneficios y riesgos. Los regímenes que son más comunes en Estados Unidos son carboplatino con paclitaxel una vez por semana. Una vez que se acaban las cuatro a seis semanas de radiación, se dan otros dos ciclos que se llaman ciclos de consolidación. El otro régimen que es muy común es cisplatino con etopósido y esto se da dos ciclos de quimioterapia durante la radiación sin hacer quimioterapias adicionales.


  

English TRANSCRIPT

When the patient is in stage three and is not a candidate to surgery because the cancer is in some lymph nodes of the mediastinum or other reasons, the best option is chemotherapy with radiation at the same time. The radiation is given every day for four to six weeks and the chemotherapy, depending on the regimen chosen, can be once per week or two cycles of chemotherapy during the entire treatment of radiation.

The types of chemotherapies are controversial because to choose which one is better depends on the discussion you have with your doctor to know the time they have, the risks and benefits. The most common regimens in United States are carboplatin and paclitaxel once per week. Once the four to six weeks are over, two more cycles of radiation are given to consolidate. The other common regimen is cisplatin with etoposide, they are given in two cycles of chemotherapy during the radiation with no additional chemotherapies.


Denise Brock

Lung Cancer Video Library – Spanish Language: Video #22 Treating Stage III Unresectable NSCLC

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GRACE Cancer Video Library - Lung

 

We continue to provide informational videos for our Spanish speaking community and welcome Dr. Luis Raez, MD FACP FCCP, Chief of Hematology/Oncology and Medical Director at Memorial Cancer Institute, and Clinical Associate Professor of Medicine at Florida International University.  Dr. Raez joined GRACE to discuss the basics of lung cancer.  In this 22nd video for the Spanish lung cancer video library, Dr. Raez discusses treating stage III unresectable NSCLC.


 

 

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TRANSCRIPTS – Spanish and English
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Tratamiento para el cáncer de pulmón en estadio III no operable

En el caso de estadio IIIB no se pueden resecar, porque tienen un tumor que está invadiendo el mediastino y los grandes vasos. Normalmente ese tumor se podía sacar porque no hay metástasis, pero ya que la localización no es adecuada, no se puede sacar.

El tratamiento para un tumor en estadio IIIB cuando el tumor es inoperable, es dar quimioterapia con radioterapia al mismo tiempo. Como ustedes saben por un estudio famoso del grupo HOG, sabemos que el estándar es quimioterapia con cisplatino- etopósido y radiación, pero cisplatino-etopósido es una quimioterapia un poco antigua y tóxica. Por lo que hoy en día a pesar de que ese es el estándar de los grupos cooperativos americanos que usamos de referencia, preferimos dar carboplatino y paclitaxel, que es una quimioterapia fácil de manejar y que se da semanalmente.

Incluso en Estados Unidos, tenemos pacientes de edad mayor de 80-85 años que no van a tolerar el cisplatino ni etopósido, por eso el régimen de carboplatino-paclitaxel semanal es la quimioterapia de elección en estos estadios. Así que es muy importante tener estos criterios en cuenta cuando abordamos a los pacientes.


Treatment for lung cancer in stage III unresectable

In the case of stage III, is unresectable because they have a tumor invading the mediastinum or the great vessels. Usually this tumor would have been able to be resectable because it didn’t have metastasis, but the location is not adequate so that’s why it’s unresectable.

Treatment for a stage IIIB unresectable tumor is chemotherapy and radiotherapy at the same time. As you know, based in a famous trial by the group HOG, we know that the standard treatment is with cisplatin- etoposide and radiation, but cisplatin-etoposide is an old and toxic chemotherapy. So today, despite the standard American cooperative groups treatment, we prefer to use carboplatin and paclitaxel, which is a chemotherapy easy to handle and it’s given weekly.

Even in United States, we have elderly patients of 80-85 years old that will not tolerate cisplatin nor etoposide, so the weekly regimen of carboplatin- paclitaxel is the go therapy in these stages. So, it is very important to have these criteria when we are approaching the patients.


GRACE Video

Clinical Trial Spotlight: Determining Efficacy of Immunotherapy in Stage III Lung Cancer

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LCAM 2015

 

Dr. Ben Levy discusses two trials that are trying to determine if immunotherapy can help lung cancer patients with earlier stage disease. Get more information about the PACIFIC trial. The lung cancer vaccine trial will begin in early 2016.

November is Lung Cancer Awareness Month. What are you grateful for?

Watch, read, and then share your own stories of empowerment in our online forum. Your story may inspire others.

Get more information about the PACIFIC trial.

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