GRACE :: Lung Cancer

Targeted Therapies

Denise Brock

Lung Cancer Video Library – Spanish Language: Video #34 Acquired Resistance to Targeted Therapies: Biology and Different Clinical Patterns

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GRACE Cancer Video Library - Lung

 

We continue to provide informational videos for our Spanish speaking community and welcome Dr. Luis Raez, MD FACP FCCP, Chief of Hematology/Oncology and Medical Director at Memorial Cancer Institute, and Clinical Associate Professor of Medicine at Florida International University.  Dr. Raez joined GRACE to discuss the basics of lung cancer.  In this 34th video for the Spanish lung cancer video library, Dr. Raez discusses acquired resistance to targeted therapies: biology and different clinical patterns.


 

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TRANSCRIPTS – Spanish and English
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Resistencia adquirida a terapias dirigidas: biología y diferentes patrones clínicos

Acquired resistance to targeted therapies: biology and different clinical patterns

 Dr. Luis Raez, MD FACP FCCP

Chief of Hematology/Oncology and Medical Director, Memorial Cancer Institute,
Clinical Associate Professor of Medicine, Florida International University

 

Spanish TRANSCRIPT

Lamentablemente, a pesar que es muy emocionante ver como los pacientes que tienen las mutaciones de EGFR y las translocaciones ALK responden al inicio, sabemos que los tumores van a crear resistencia a estos agentes.

Usualmente es a los 10 o 12 meses que la mitad de los pacientes que están en estas terapias blanco, genera resistencia por muchas razones. Por ejemplo, en los receptores de EGFR, aparecen nuevas mutaciones como la mutación EGFRT790. En el caso de las translocaciones de ALK, también aparecen otras variantes nuevas que no están al comienzo que son variantes asociadas y documentadas para resistencia.

A pesar de que hay sensibilidad al comienzo, tenemos que estar alerta y monitorizando ya sea con radiografía o próximamente vamos a tener biopsias líquidas que vamos a poder estar monitorizando en la sangre para ver cuando empiezan la clonas resistentes a aparecer y en qué momento hay que empezar a cambiar la terapia.

Como ustedes saben felizmente, en el caso de la EGFR, cuando aparece resistencia tenemos otras terapias blanco como osimertinib. En el caso de las translocaciones ALK tenemos otras terapias blanco a parte de crisotinib que se usa al comienzo, tenemos ceritinib, alectinib y otros fármacos más que están por venir.

 


 

 

English TRANSCRIPT

Unfortunately, despite the excitement of seeing patients with EGFR mutations and ALK translocations responding great to the treatment, we know that these tumors will create resistance to the therapy.

Usually at 10 or 12 months, half targeted therapy patients create resistance for many reasons. For example, in EGFR receptors, new mutations arise like EGFRT790. In ALK translocations, new variants appear that are associated and documented to resistance.

Despite there is sensitivity at the beginning, we have to be alert and monitoring with a radiography or in the near future with a liquid biopsy where we will be able to monitor blood and see when the resistant clones start to develop, and then change the therapy.

As you know, in EGFR when resistance starts, we have other new targeted therapies like osimertinib. In the ALK translocations, we have other targeted therapies besides crisotinib that is used in the beginning. We also have ceritinib, alectinib and other drugs that are coming.

 


Denise Brock

Lung Cancer Video Library – Spanish Language: Video #18 Acquired Resistance to Targeted Therapies: Biology and Different Clinical Patterns

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GRACE Cancer Video Library - Lung

 

For our 18th video in the GRACE Spanish Lung Cancer Library, Dr. Brian Hunis, Medical Director, Head and Neck Cancer Program, Memorial Cancer Institute, Miami, Florida, joined GRACE to discuss the basics of Lung Cancer for Spanish-speaking patients and caregivers.  In this video Dr. Hunis addresses acquired resistance to targeted therapies: biology and different clinical patterns.


 

 

 

 


 

How Did You Like This Video?

Please feel free to offer comments and raise questions in our Discussion Forums.


 

TRANSCRIPTS – Spanish and English
download transcripts

Resistencia adquirida a las terapias dirigidas: Biología y diferentes patrones clínicos.

Lamentablemente inclusive en pacientes que tienen la translocación de ALK, eventualmente los pacientes van a desarrollar una resistencia adquirida, por lo cual la medicación con crizotinib no va a funcionar mas.

Por lo general, estos son pacientes que van a tener un prelapso o una recaída en sistema nervioso central o pulmón. Esos son pacientes a los cuales que uno va a considerar terapia de segunda línea o cambiar a quimioterapia.


Acquired resistance to targeted therapies: biology and different clinical patterns.

Unfortunately, even patients with ALK translocation will eventually develop an acquired resistance, resulting in crisotinib not working anymore.

In general, these patients will have a relapse or re-fall in the central nervous system or lung. In these patients, we will consider a second line therapy or change to chemotherapy.


Denise Brock

Targeted Therapies in Lung Cancer Patient Forum 2016 – Recharging Batteries

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Presented by the

Global Resource for Advancing Cancer Education
in collaboration with
the University of Colorado
Cancer Center
 
On August 20, 2016, in collaboration with the University of Colorado Cancer Center, GRACE presented the Targeted Therapies in Lung Cancer Patient Forum in Aurora, Colorado.  In this sixteenth and final video, the eighth from the afternoon breakout survivorship sessions, we present “Recharging the Caregivers Batteries”, with Jeanice Hansen, MSW, LCSW, OSW-C.

Download the Agenda and Speaker Bios

(click for speaker slides and downloads)
Recharging the caregivers batteries
 


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Denise Brock

Targeted Therapies in Lung Cancer Patient Forum 2016 – Marijuana Use

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Presented by the

Global Resource for Advancing Cancer Education
in collaboration with
the University of Colorado
Cancer Center
 
On August 20, 2016, in collaboration with the University of Colorado Cancer Center, GRACE presented the Targeted Therapies in Lung Cancer Patient Forum in Aurora, Colorado.  In this fifteenth video, the seventh from the afternoon breakout survivorship sessions, we present “Where There’s Smoke, Is There Fire? Marijuana and Lung Cancer“, presented by Dr. Dan Bowles.

Download the Agenda and Speaker Bios

(click for speaker slides and downloads)
Where there’s smoke, is there fire?
 


How Did You Like This Video?

Please feel free to offer comments and raise questions in our Discussion Forums.

 

Denise Brock

Targeted Therapies in Lung Cancer Patient Forum 2016 – Love, Sex and Cancer

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Presented by the

Global Resource for Advancing Cancer Education
in collaboration with
the University of Colorado
Cancer Center
 
On August 20, 2016, in collaboration with the University of Colorado Cancer Center, GRACE presented the Targeted Therapies in Lung Cancer Patient Forum in Aurora, Colorado.  In this fourteenth video, the sixth from the afternoon breakout survivorship sessions, we present Love, Sex, and Cancer, with Dr. Helen Coons.

Download the Agenda and Speaker Bios

(click for speaker slides and downloads)
Sexual Functioning in Adults, Lung Cancer
 


How Did You Like This Video?

Please feel free to offer comments and raise questions in our Discussion Forums.

 

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