GRACE :: Lung Cancer

Treatment

Denise Brock

Lung Cancer Video Library – Spanish Language: Video #44 Treatment of Stage III Unresectable Non-Small Cell Lung Cancer

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We are pleased to continue this series of informational videos for our Spanish speaking community.  GRACE is pleased to welcome Dr. Rafael Santana-Davila, Assistant Professor with the University of Washington School of Medicine and Seattle Cancer Care Alliance.  In this 44th video for the Spanish lung cancer video library, Dr. Santana-Davila joined GRACE to discuss the treatment of stage 3 unresectable non-small cell lung cancer.


 

 

 

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TRANSCRIPTS – Spanish and English
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Tratamiento de Cancer de Pulmón de Células no Pequeñas en Estadio Tres no Resecable

Treatment of Stage III Nonresectable Non-Small Cell Lung Cancer

 

Rafael Santana-Davila, MD
Assistant Professor of Medicine
University of Washington Seattle Cancer Care Alliance
Seattle, Washington

 

Spanish TRANSCRIPT

Cuando el paciente se encuentra en estadio tres y no es candidato a cirugía porque el cancer está en varios ganglios del mediastino o por otras razones, lo que hacemos es quimioterapia con radiación al mismo tiempo. La radiación se da todos los días por cuatro a seis semanas y la quimioterapia dependiendo de qué régimen se escoge puede ser una vez por semana o dos ciclos de quimioterapia durante la radiación.

Para saber cuál quimioterapia es mejor es un poco controversial, pero depende mucho de la plática que se tiene con el paciente para conocer el tiempo que se tiene, los beneficios y riesgos. Los regímenes que son más comunes en Estados Unidos son carboplatino con paclitaxel una vez por semana. Una vez que se acaban las cuatro a seis semanas de radiación, se dan otros dos ciclos que se llaman ciclos de consolidación. El otro régimen que es muy común es cisplatino con etopósido y esto se da dos ciclos de quimioterapia durante la radiación sin hacer quimioterapias adicionales.


  

English TRANSCRIPT

When the patient is in stage three and is not a candidate to surgery because the cancer is in some lymph nodes of the mediastinum or other reasons, the best option is chemotherapy with radiation at the same time. The radiation is given every day for four to six weeks and the chemotherapy, depending on the regimen chosen, can be once per week or two cycles of chemotherapy during the entire treatment of radiation.

The types of chemotherapies are controversial because to choose which one is better depends on the discussion you have with your doctor to know the time they have, the risks and benefits. The most common regimens in United States are carboplatin and paclitaxel once per week. Once the four to six weeks are over, two more cycles of radiation are given to consolidate. The other common regimen is cisplatin with etoposide, they are given in two cycles of chemotherapy during the radiation with no additional chemotherapies.


Denise Brock

Lung Cancer Video Library – Spanish Language: Video #43 The Treatment of Early Stage Non-Small Cell Lung Cancer

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GRACE Cancer Video Library - Lung

 

We are pleased to continue this series of informational videos for our Spanish speaking community.  GRACE is pleased to welcome Dr. Rafael Santana-Davila, Assistant Professor with the University of Washington School of Medicine and Seattle Cancer Care Alliance.  In this 43rd video for the Spanish lung cancer video library, Dr. Santana-Davila joined GRACE to discuss  the treatment of early stage non-small cell lung cancer.


 

 

 

How Did You Like This Video?

Please feel free to offer comments and raise questions in our Discussion Forums.


 

TRANSCRIPTS – Spanish and English
download transcripts
 

Tratamiento de Cancer de Células no Pequeñas Cuando Están en un Estadio Temprano

Treatment of Early Stage Non-small Cell Lung Cancer

 

Rafael Santana-Davila, MD
Assistant Professor of Medicine
University of Washington Seattle Cancer Care Alliance
Seattle, Washington

 

Spanish TRANSCRIPT

El cancer de pulmón cuando se encuentra en estadio I o II, el mejor tratamiento es cirugía tratando de quitar el cancer. En la mayoría de las veces, lo que se hace es llevar el paciente a cirugía, quitar el cancer de donde está quitando todo el lóbulo del pulmón y muchos de los ganglios de alrededor. Si los ganglios no están involucrados, el tratamiento es quirúrgico sin ninguno otro tratamiento adicional. Si los ganglios están involucrados, se dará también quimioterapia adyuvante después de la cirugía para erradicar pequeñas células que estén en otros lados del cuerpo. El objetivo del tratamiento es tratar de curar al paciente.

El problema de muchos pacientes es que la cirugía puede ser muy peligrosa porque el pulmón de estos pacientes no es sano y quitar un lóbulo de un pulmón pude ser muy dañino. En estos casos, también se puede tratar con una radiación local. 


  

English TRANSCRIPT

When the lung cancer is in stage one or two, the best treatment is surgery to try to remove the cancer. In most cases, the patient goes into surgery where they eliminate the cancer by removing the lobe of the lung and some of the lymph nodes nearby. If the lymph nodes are not involved, the treatment is only surgical. However, if the lymph nodes are involved, after the surgery the patient has to take adjuvant chemotherapy to eradicate small cells that are in other parts of the body. The main goal is to try to cure the patient.

The problem in some patients is that surgery can be very dangerous because the lung in these patients is not a healthy lung, so by removing its lobe can be quite harmful. In these cases, the treatment can be just local radiation.


Denise Brock

Lung Cancer Video Library – Spanish Language: Video #18 Acquired Resistance to Targeted Therapies: Biology and Different Clinical Patterns

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GRACE Cancer Video Library - Lung

 

For our 18th video in the GRACE Spanish Lung Cancer Library, Dr. Brian Hunis, Medical Director, Head and Neck Cancer Program, Memorial Cancer Institute, Miami, Florida, joined GRACE to discuss the basics of Lung Cancer for Spanish-speaking patients and caregivers.  In this video Dr. Hunis addresses acquired resistance to targeted therapies: biology and different clinical patterns.


 

 

 

 


 

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TRANSCRIPTS – Spanish and English
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Resistencia adquirida a las terapias dirigidas: Biología y diferentes patrones clínicos.

Lamentablemente inclusive en pacientes que tienen la translocación de ALK, eventualmente los pacientes van a desarrollar una resistencia adquirida, por lo cual la medicación con crizotinib no va a funcionar mas.

Por lo general, estos son pacientes que van a tener un prelapso o una recaída en sistema nervioso central o pulmón. Esos son pacientes a los cuales que uno va a considerar terapia de segunda línea o cambiar a quimioterapia.


Acquired resistance to targeted therapies: biology and different clinical patterns.

Unfortunately, even patients with ALK translocation will eventually develop an acquired resistance, resulting in crisotinib not working anymore.

In general, these patients will have a relapse or re-fall in the central nervous system or lung. In these patients, we will consider a second line therapy or change to chemotherapy.


Denise Brock

Lung Cancer Video Library – Spanish Language: Video #17 First Line Therapy for NSCLC Patients That Have Anaplastic Lymphoma Kinase (ALK) Positive

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GRACE Cancer Video Library - Lung

 

For our 17th video in the GRACE Spanish Lung Cancer Library, Dr. Brian Hunis, Medical Director, Head and Neck Cancer Program, Memorial Cancer Institute, Miami, Florida, joined GRACE to discuss the basics of Lung Cancer for Spanish-speaking patients and caregivers.  In this video Dr. Hunis speaks about first line therapy for non-small cell lung cancer patients that have anaplastic lymphoma kinase (ALK) positive.


 

 

 

 


 

How Did You Like This Video?

Please feel free to offer comments and raise questions in our Discussion Forums.


 

TRANSCRIPTS – Spanish and English
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Terapia de primera línea para pacientes con cáncer pulmonar de células no pequeñas que presentan la cinasa de linfoma anaplásico (CLA) positiva.

En los pacientes en los cuales uno describe que el adenocarcinoma de pulmón de células no pequeñas tiene la translocación del gen ALK, hay terapia dirigida que atacan exclusivamente a las células que expresan esa mutación. Por lo cual los efectos adversos, la toxicidad y las respuestas son muchísimo mejores.

La primera terapia para pacientes con translocación en ALK que se ha usado en el mundo es con crisotinib. Crisotinib es una píldora que se toma diariamente, es bien tolerada y con efectos muy positivos.


First line therapy for non-small cell lung cancer patients that have the anaplastic lymphoma kinase positive.

In patients that have adenocarcinoma of non-small cells and also have the ALK gene translocation, there is a targeted treatment that only attacks the cell that express this mutation. So, the side effects, toxicity and the response are better.

The first therapy for patients with the ALK translocation that has been used in the world is with crisotinib. Crisotinib is a pill that is taken daily, is well tolerated and with very positive effects.


Denise Brock

Lung Cancer Video Library – Spanish Language: Video #16 ALK Rearrangements: What Are They and Which Patients Have Them?

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GRACE Cancer Video Library - Lung

 

For our 16th video in the GRACE Spanish Lung Cancer Library, Dr. Brian Hunis, Medical Director, Head and Neck Cancer Program, Memorial Cancer Institute, Miami, Florida, joined GRACE to discuss the basics of Lung Cancer for Spanish-speaking patients and caregivers.  In this video Dr. Hunis speaks about ALK rearrangements, what they are and who has them.  


 

 

 

 


 

How Did You Like This Video?

Please feel free to offer comments and raise questions in our Discussion Forums.


 

TRANSCRIPTS – Spanish and English
download transcripts

Reacomodos de la Cinasa de Linfoma Anaplásico (CLA): ¿Qué Son? Y ¿Qué Pacientes la Tienen?

El cancer de pulmón de células no pequeñas ha demostrado tener mutaciones genéticas que hacen que ese cancer se pueda desarrollar y crezca. Una de esas mutaciones presente en menos del 10% de los pacientes es la mutación o translocación del gen ALK.

Es mutación o translocación permite que una proteína oncogénica se desarrolle, con lo cual los pacientes están predispuestos a desarrollar cancer de pulmón de células no pequeñas.

Por lo general, esos son pacientes no fumadores, de sexo femenino o con una historia remota de consumo de tabaco de forma remota o muy limitada.


Rearrangements of the Anaplastic Kinase Lymphoma (ALK): What Are They? And, What Patients Have Them?

Non-small cell lung cancer has proved to have many mutations that make the cancer develop and grow. One of these mutations is in less than 10% of them and it’s the mutation or translocation of the ALK gene.

This mutation or translocation allows an oncogenic protein to develop, so these patients will be predisposed to develop non-small cell lung cancer.

In general, these are non-smokers, feminine patients or with a history of limited tobacco consumption.


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