PD-1 Clinical Studies – BMS vs. MK

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This topic contains 14 replies, has 5 voices, and was last updated by  justtina 2 years, 5 months ago.

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July 3, 2012 at 7:54 pm  #12382    

justtina

What’s the difference between the BMS and MK Pd-1 studies? The BMS studies seem to be on hold while the MK 3475 seem to be currently available.


Husband 53, never smoked. Diagnosed 7/2011; NSCLC Stage IV, Adeno. ALK/EGFR/KRAS (-). Wild Type. Brain metastasis. 8/11-Carboplatin; 12/11-remission / begin Alimta; 2/12-progression / begin Tarceva (w/o EGFR result); 3/12-begin WBR; 4/12-cont.’d lung progression / begin Taxotere; 6/12-mixed results / gemzar recommended. Brain lesions in remission. 7/16 begin PD-1 clinical trial.

July 4, 2012 at 10:00 am  #12393    

FeistyD

Good question. I am in the MK 3475 trial. I can’t tell you yet how it is working, but as soon as I have my first set of scans I will post. But based on anecdotal evidence (I feel MUCH better with no side effects- cough is GONE) I would try to get in any anti-PD 1 trial that I could.

July 4, 2012 at 10:59 am  #12394    

catdander forum moderator

FeistyD, it’s great to hear you’re doing so well. I will follow this one closely since my husband fits into the possible responders. Other than the makers MK (Merck) and BMS (Bristol Myers Squibb) they’re targeting the same pd-1 or pd-l1. BMS doesn’t seem to have their followup trials on board yet.


My husband, 53 @ dx of stage 3 squam nsclc R. pancoast tumor 8/09 caused destruction of 3 ribs, touching brachial plexus. 2 core and 1 VATS undx biopsies. Open thoracotomy for 1 positive biopsy (unresectable). Chemorads, 9/09. MRI by pancoast specialty surgeon 11/09 spine met found, stage IV, Rad to spine, Chemo changed from cis/etop to navelbine/carbo. 6 cycles total. Tarceva 2/10-11/10. 3cm tumor L lung, biopsy undx w/collapsed lung. Gemzar, 12/10 through 7/12. NED 3/12, stop tx 7/12. Remains NED as of 8/14.

July 4, 2012 at 11:11 am  #12395    

Dr West

They’re both antibodies to PD-1, but one is developed by Medarex, which was bought up (or at least partnered with) Bristol-Myers Squibb, while the MK one is being developed by Merck/Schering-Plough. They’re just on slightly different timetables. A phase I trial of MK-3475 was reported at ASCO and showed no consistent dose-limiting toxicities or maximal tolerated dose.

It’s typical for companies to regroup to plan their next research steps. I’m certain that BMS is planning to move forward with their anti-PD-1 work as expeditiously as possible, and I’m also sure they’ll have plenty of interest. In fact, my center is in the process of activating a randomized trial of the BMS vaccine vs. Taxotere (docetaxel) for previously treated patients with advanced NSCLC.

-Dr. West


Howard (Jack) West, MD
Medical Oncologist

Views expressed here represent my opinion, not those of GRACE or Swedish Cancer Institute. This information does not constitute medical advice and is intended to supplement and not replace medical information provided by your doctor.

July 5, 2012 at 9:03 am  #12437    

justtina

Thanks, all. I thought it was interesting that I had trouble finding info. about existing trials online. We got lucky, however, and may be joining Feisty D at the Angeles clinic for the MK-3475 trial or we may be able to join the same trial at UCLA as well.

FeistyD — Its great to know you’re already seeing improvement. I look forward to hearing that its working well for you!


Husband 53, never smoked. Diagnosed 7/2011; NSCLC Stage IV, Adeno. ALK/EGFR/KRAS (-). Wild Type. Brain metastasis. 8/11-Carboplatin; 12/11-remission / begin Alimta; 2/12-progression / begin Tarceva (w/o EGFR result); 3/12-begin WBR; 4/12-cont.’d lung progression / begin Taxotere; 6/12-mixed results / gemzar recommended. Brain lesions in remission. 7/16 begin PD-1 clinical trial.

July 6, 2012 at 6:33 am  #12474    

FeistyD

Justtina, I was at the Angeles Clinic yesterday for my 3rd treatment of MK 3475. Let me know if you join the trial there- it’s really a great place. I know one has to have a clear brain scan as one of the trial criteria. I really hope your husband qualifies because so far this drug is SO much better than chemo on every level, at least for me.

July 6, 2012 at 10:43 am  #12481    

justtina

Feisty D — we were also there yesterday in the late afternoon for an initial appt. And, we’re also hopeful that he’ll pass all tests qualifying him for the trial. We need to decide whether to join the trial at UCLA or Angeles Clinic (AC). It seems AC has more experience with PD-1 trials and is also running a related trial that he may be eligible for even if the brain scan shows progression.


Husband 53, never smoked. Diagnosed 7/2011; NSCLC Stage IV, Adeno. ALK/EGFR/KRAS (-). Wild Type. Brain metastasis. 8/11-Carboplatin; 12/11-remission / begin Alimta; 2/12-progression / begin Tarceva (w/o EGFR result); 3/12-begin WBR; 4/12-cont.’d lung progression / begin Taxotere; 6/12-mixed results / gemzar recommended. Brain lesions in remission. 7/16 begin PD-1 clinical trial.

July 6, 2012 at 10:56 am  #12483    

FeistyD

Having been a patient at both UCLA (not for cancer) and the Angeles Clinic (just down the road), I have to say I prefer AC for several reasons: it’s smaller, so there is less bureaucracy, easier parking, better food options (across the street and down Wilshire), and friendlier staff. You really get to know the staff there. Also I had some crazy billing problems with UCLA (they had me down as a Medicare patient even though I was 55 at the time and very carefully presented them my insurance cards). Then my insurance (Blue Shield) dropped UCLA from the network over a contract dispute. But, of course, UCLA has some great stuff going on there (I’m a Bruin and so is my daughter, but we’re not biased- my primary doctor is at USC). You really can’t lose. Getting in the trial is the main thing.

July 6, 2012 at 12:02 pm  #12486    

justtina

Thanks. Very helpful! We visited both UCLA and AC this week and feel very fortunate to have the options…now we just have to be eligible (small hurdle:)

We were very comfortable with Dr. Goldman and UCLA. He’s aggressive and the office in SM was easy to get to. We did also like the very personable staff and vibe at AC and the fact that they’re more nimble than larger centers such as UCLA. But battling the traffice to reach ACs WLA office was stressful and draining.

Both locations seem to have other options available in case test results show we are not eligible for PD-1.
At the end of the day, we’re just praying we get into the trial.


Husband 53, never smoked. Diagnosed 7/2011; NSCLC Stage IV, Adeno. ALK/EGFR/KRAS (-). Wild Type. Brain metastasis. 8/11-Carboplatin; 12/11-remission / begin Alimta; 2/12-progression / begin Tarceva (w/o EGFR result); 3/12-begin WBR; 4/12-cont.’d lung progression / begin Taxotere; 6/12-mixed results / gemzar recommended. Brain lesions in remission. 7/16 begin PD-1 clinical trial.

July 6, 2012 at 10:30 pm  #12512    

Dr West

I know Dr. Goldman and consider him a good doctor, smart about lung cancer, and also know some people who have worked with him and found him to communicate/connect very well with patients.

-Dr. West


Howard (Jack) West, MD
Medical Oncologist

Views expressed here represent my opinion, not those of GRACE or Swedish Cancer Institute. This information does not constitute medical advice and is intended to supplement and not replace medical information provided by your doctor.

July 7, 2012 at 11:58 am  #12547    

justtina

Good to know. Are you familiar with the Angeles Clinic and Dr. Hamid?


Husband 53, never smoked. Diagnosed 7/2011; NSCLC Stage IV, Adeno. ALK/EGFR/KRAS (-). Wild Type. Brain metastasis. 8/11-Carboplatin; 12/11-remission / begin Alimta; 2/12-progression / begin Tarceva (w/o EGFR result); 3/12-begin WBR; 4/12-cont.’d lung progression / begin Taxotere; 6/12-mixed results / gemzar recommended. Brain lesions in remission. 7/16 begin PD-1 clinical trial.

July 7, 2012 at 1:14 pm  #12552    

Dr West

I’m not. That doesn’t mean that they aren’t very good. I just don’t know of them.

-Dr. West


Howard (Jack) West, MD
Medical Oncologist

Views expressed here represent my opinion, not those of GRACE or Swedish Cancer Institute. This information does not constitute medical advice and is intended to supplement and not replace medical information provided by your doctor.

July 7, 2012 at 2:52 pm  #12554    

certain spring

I hope the two of you get the opportunity to meet!


49-year-old non-smoker, dx stage IV NSCLC May 2010 (squamous tumour of the left lung with multiple brain metastases). Radiotherapy to chest and brain; progressed through two cycles carbo/gemcitabine. Repeated lung collapses; pneumonia in collapsed lung, Nov 2010; bronchial stent placed, Dec 2010. Declined second-line Taxotere. Mutation testing Feb 2011, surprise EGFR exon deletion 19. Started Tarceva (150mg), Feb 2011. Progression in liver and elsewhere, May 2013.

July 7, 2012 at 3:32 pm  #12558    

FeistyD

Hamid’s my doctor so I’m a bit prejudiced, but I believe he’s saving my life. He told me he’s not a lung cancer specialist (his cancer area of interest is melanoma)- his focus is on immunotherapy and drug development. He has me seeing my referring lung cancer oncologist every few months. I had never heard of the Angeles Clinic either, before I became a patient, but there are people coming in from Alaska, Hong Kong, and Russia for the clinical trials, so I guess I can’t complain about spending an hour on the 405 freeway to get there. It’s not a big research hospital- everyone there seems to be in a clinical trial.

July 7, 2012 at 10:39 pm  #12576    

justtina

Thanks, FeistyD! We’ll be following in your footsteps and will keep you posted on our progress as well. We’ll be in for testing next week and hope to begin within the next 2 weeks or so. Maybe we’ll see you at the clinic someday soon.


Husband 53, never smoked. Diagnosed 7/2011; NSCLC Stage IV, Adeno. ALK/EGFR/KRAS (-). Wild Type. Brain metastasis. 8/11-Carboplatin; 12/11-remission / begin Alimta; 2/12-progression / begin Tarceva (w/o EGFR result); 3/12-begin WBR; 4/12-cont.’d lung progression / begin Taxotere; 6/12-mixed results / gemzar recommended. Brain lesions in remission. 7/16 begin PD-1 clinical trial.

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