Toptocan Question

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This topic contains 3 replies, has 3 voices, and was last updated by  Dr West 2 years, 1 month ago.

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March 14, 2012 at 5:43 am  #7661    

rsmith8167

My mother in law was dx with extensive SCLC in July 2011 we have done 6 rounds of chemo, 6 rounds of cyber knife and 14 WBR. The doctor also thinks the cancer has gotten into her bones so Monday we started Zometa. My question for you is after the 6 rounds rounds of chemo we did a CT scan 3 months later and it showed the lung cancer has gotten to the size it was when we started chemo, I know that isn\\’t good by what I have read on this web site. Her dr wants her to look into trial study\\’s I have found one and wanted to see if you have heard anything about it is Linisitinibor or Topotecan. I know Topotecan is the next round of chemo she would get anyway because it came back so quickly. So also can you please tell me what you know about the study we go Tuesday to talk to the dr and I would like to have as much info I can so I know what questions I should ask.
The trail study number is NCT 01533181
Thank you so much for doing what you do on this web site I know a lot of people look at you for answers you are doing a wonderful thing here. Thank you again for answering my questions.

I hope this is the right place to put questions I think the last place was wrong.

We went to the dr yesterday they said there is no trail going on right now I am not sure why she can\’t do the trail I mentioned above but I am going to email the dr and find out. My question is we will start Toptocan Monday I would like to know side effects she might have and anything else that might be helpful. I also seen there is a pill you can take is that as good as the IV?

March 14, 2012 at 6:49 am  #7663    

certain spring

Hallo, rsmith, and I am very sorry to hear about your mother-in-law.
I just wanted to be clear about what your question is. You previously posted here:
http://cancergrace.org/topic/entensive-sclc
asking about this trial of Topotecan and lisitinib:
http://www.clinicaltrials.gov/ct2/show/NCT01533181.
But I think the new question is about the side-effects of Topotecan, and the difference between taking it in pill form, and via IV? While you’re waiting for a doctor to answer, some of the side-effects are described here (you need to scroll down to “second-line treatments”):
http://cancergrace.org/lung/2010/08/07/treatment-of-small-cell-lung-cancer/
Very best to your mother-in-law.


49-year-old non-smoker, dx stage IV NSCLC May 2010 (squamous tumour of the left lung with multiple brain metastases). Radiotherapy to chest and brain; progressed through two cycles carbo/gemcitabine. Repeated lung collapses; pneumonia in collapsed lung, Nov 2010; bronchial stent placed, Dec 2010. Declined second-line Taxotere. Mutation testing Feb 2011, surprise EGFR exon deletion 19. Started Tarceva (150mg), Feb 2011. Progression in liver and elsewhere, May 2013.

March 14, 2012 at 8:23 am  #7664    

rsmith8167

Thank You certain spring for replying I am sorry that I wasn’t clear. I am new to this. I was looking at the trail study NCT01533181 for my MIL but when we went to the DR yesterday they said she couldn’t go on that study I am trying to find out why (the reason I didn’t ask yesterday I didn’t have the info with me I thought they would know all the trails going on at their hospital) I have emailed the DR we seen yesterday. The DR said yesterday the only thing we could do right now is go on Toptocan so I am trying to find out everything I can about it like what to expect from it and the side effects.

March 14, 2012 at 1:48 pm  #7674    

Dr West

The leading side effects with topotecan are related to low blood counts and the complications this can lead to, primarily fatigue, need for transfusions, increased risk of infection, possibly bleeding…

Here are some posts that discuss oral and IV topotecan:

http://cancergrace.org/lung/2010/08/07/treatment-of-small-cell-lung-cancer/

http://cancergrace.org/lung/2008/03/01/po-topo-2nd-line-nsclc/

We sometimes give the topotecan weekly (one day per week) instead of for 5 days in a row every three weeks. While the latter schedule is better studied, it can be so challenging that we are often inclined to consider alternatives that may offer a better balance of activity and quality of life for patients.

Good luck.

-Dr. West


Howard (Jack) West, MD
Medical Oncologist

Views expressed here represent my opinion, not those of GRACE or Swedish Cancer Institute. This information does not constitute medical advice and is intended to supplement and not replace medical information provided by your doctor.

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