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    • Dr West We have no information to speak to that question. (More)
    • Has Selumetinib for NSCLC (ROS1 rearrangement positive) shown any promise?? How does that drug compare with pemetrexed? Are there any clinical trials or results available? (More)
    • Dr West Chemotherapy is the current leading recommendation. Many people have observed that patients with a ROS1 rearrangement often respond very well to a regimen that includes pemetrexed. -Dr. West (More)
    • Thank you for your prompt reply. If Alectinib is not recommended for 1st or 2nd line treatment--what are the possibilities for 2nd line treatment of the ROS1 rearrangement when the crizotinib fails? (More)
    • Dr West No. ROS1 is a distinct molecular marker, and crizotinib tends to work especially well for it, while several of the second generation ALK inhibitors do not, so we cannot generalize results from ALK-positive patients to those with a ROS1 rearrangement. -Dr. West (More)
    • Does this information also apply to the ROS-1 positive NSCLC Stage IV? (More)
    • Dr West I'm very sorry to hear about your mother's diagnosis and recent issues. Pneumonitis tends to come on early when it occurs, but this is an uncommon to rare side effect in a new drug that we just don't have a lot of experience with yet. It will make sense to make a very careful judgment among ever (More)
    • Dear Dr. West, My mother was placed on Tagrisso as first line agent because of some evidence of possible leptomeningeal disease on MRI after WBR and some evidence that Tagrisso at 160 worked for a few patients with it. She is being followed at the NIH. She now has a possibility of very early in (More)
    • Just as my oncologist was ready to submit my tissue for PD-l1 testing to get me on Keytruda after Alimta maintenance failed me, Oodivo was approved. We decided to save my tissue and the expense of testing since Opdivo had no requirement. I see a time when these very expensive drugs will be required (More)
    • Dr West I think that at age 42, that's a lot of surveillance for a very long time, and I would be very surprised if there's never anything that leads someone to favor taking it out. Particularly if there's a single focus, I think it's very appropriate to deal with it definitively. My comments are more relev (More)
    • Dr. West, A month ago, my husband had a solid pulmonary nodule in his right lower lobe detected as an incidental finding on abdominal CT. It measure 2.5x2.6x2.2cm. PET was negative, but did show "minimal fdg uptake not significantly above background" radiologist stated that although there was not (More)
    • Dr West There is a small but real risk of pneumonitis, which is a significant side effect if you get it -- but only a very small minority of patients do.. I think the benefit outweighs risk if someone needs a new treatment, but not necessarily if the current treatment is working. Good luck. -Dr. West (More)
    • Dear Dr West, I really appreciated your article above. I am currently in Clovis Tiger I trial, taking Rocelitinib due to Stage IV non-small cell lung cancer (adenocarcinoma) that is EGFR positive. After about 7 months, my disease is stable and I have no significant side effects. I read your article (More)
    • salomon越野跑鞋 (More)
    • Dr West Unfortunately, it's really not feasible for me to assess what's happening with so many variables and not being directly involved. I think one of the most important things would be to prune back some of the medications to rule out that one or more aren't the cause, and this is something that seems es (More)
    • Hi Dr West, Thanks for publishing your article. This is really insightful and I am actually thinking bout the same thing. I am not too sure if those treatments are doing more harm than good to my boyfriend, who was diagnosed with stage 4 adenocarcinoma in August last year. This is because he has (More)
    • Dr West I'm so glad. I know that for many people out there, you have no experience with this, and having someone be able to offer some expectations, that could really help. Good luck. I hope your father is comfortable. I'm glad he has a loving family there. -Dr. West (More)
    • Thank you, this is extremely helpful. My father is home with hospice, dying of stage IV pancreatic cancer. I have not been through this before and didn't know what to expect. This has helped make it less frightening. Hospice is an absolute blessing. (More)
    • Dr West No, this is likely directly related to the fluids he received, so it shouldn't be an ongoing issue unless he gets too large a volume of fluids in a short time. However, I should say that of course I have none of the details of his situation and that a far more appropriate source of information would (More)
    • Thank You Dr.West for Your quick and professional answer! We got the results, and as you are saying, the echo cardiogram shows diminished squeezing capacity of the heart. For now, until he doesn't get stabilized, the doctors here in my country, are not recommending continuing the chemo. I'm just (More)

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