Brca2 gene. In lung cancer

Portal Forums Breast Cancer General Breast Cancer Brca2 gene. In lung cancer

This topic contains 5 replies, has 3 voices, and was last updated by catdander forum moderator catdander forum moderator 7 months, 1 week ago.

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January 7, 2017 at 9:26 am  #1289726    

tillytots

Dear dr west
I have the brca2 gene and have had two episodes of breast cancer in 2015 I was diagnosed with squamous nsclc tn2 no mo is there any link between this genetic mutation and lung cancer ,thank you in anticipation of any answers
Tilly tots


Tilly tots

January 7, 2017 at 2:01 pm  #1289727    

cards7up

A rare variant of this gene has been linked to LC. Are you a smoker? This is where the link has been found.
Take care, Judy

http://www.medscape.com/viewarticle/826973

P.S. I am not a medical professional or room moderator but I am a two time LC survivor!


Stage IIIA adeno, dx 7/2010. SRS then chemo carbo/alimta 4x. NED as of 10/2011.
Local recurrence, surgery to remove LRL 8/29/13. 5.2cm involved pleura. Chemo carbo/alimta x3. NED

January 8, 2017 at 2:00 am  #1289728    

tillytots

Hi Judy
Yes I was a previous smoker , I managed to stop 3 years ago,too little too late I’m afraid,thank you so much for replying ,I read somewhere about a possible link I think it was on inspire website but not sure ,thank you again.


Tilly tots

January 8, 2017 at 12:54 pm  #1289733    
catdander forum moderator
catdander forum moderator

Tilly tots,

Hi and welcome to Grace. I’m very sorry to know of your multiple occurrences of cancer. Your statement that your quitting smoking was too late is incorrect. No matter when you stop it’s a good thing moving forward. My husband is a good example. He stopped when he was diagnosed, we both did. He was successful in part due to a 9 day stay in the hospital during which time he was formally diagnosed. It has been a great help to his health. His very difficult to treat squamous nsclc was cured with radiation and chemo. Smoking allowed him to tolerate treatment better and to breath easier even if still easily short of breath. So a BIG Congratulations on stopping!

I’m posting the following link with the understanding that I’ll check with one of our faculty to make sure the info is correct. I understand there to be a multitude of variants of this mutation but can’t find that there is the same on that is related to lung cancer is also related to breast cancer.

https://www.verywell.com/lung-cancer-linked-with-breast-cancer-gene-brca2-2248853

I or one of our faculty will post again within a day.
All best,
Janine

January 8, 2017 at 2:48 pm  #1289735    

tillytots

Thank you so much janine


Tilly tots

January 10, 2017 at 4:52 pm  #1289754    
catdander forum moderator
catdander forum moderator

Hi Tilly tots,

I contacted Dr. West, he stated he isn’t aware of any work on answering the question of whether the BRCA2 mutation variant that causes lung cancer is related to the BRCA mutation variant that causes breast cancer.

In my internet search I’ve not been able to find any evidence of work on it either. It’s all too possible the article I referred you to hasn’t taken into consideration that there are different variants of these mutations that can cause cancers. It’s likely that article isn’t being as specific as we are; can the same mutation you have have caused both/all your cancers. I’m afraid we can’t give you an answer though it is a very relevant question.

I hope you do well and hope you don’t get anymore cancers.
All best,
Janine

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