Bristol and Celldex collaboration

Portal Forums Cancer Basics Oncology Economics/Industry/Policy Bristol and Celldex collaboration

This topic contains 3 replies, has 3 voices, and was last updated by Dr West Dr West 3 years, 6 months ago.

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May 14, 2014 at 11:29 am  #1263752    

ssflxl

At last, the drug companies are collaborating to try combinations in their clinical trials. I hope this leads to quicker approval

http://www.thestreet.com/story/12707778/1/bristol-celldex-collaborating-on-cancer-immunotherapy-study.html

ssflxl


Non smoker Asian F, St 4 NSCLC – 11/2010, 6 cm LUL mass, met to paraspinal muscle, +EGFR at Exon 21 L858R. Tarceva in 11/2010, rad to lung mass and met. 5/2012 – PET showed inc SUV in primary cancer, new 1.6 cm lesion in left thoracic inlet causing Horner’s syndrome. Cyberknife to lesion – 5/2012. Restarted Tarceva 75mg/day -5/12, reduced to 50mg. 8/12 – PET- thoracic inlet lesion gone. 11/12 PET – inc SUV in primary tumor, ant mammary node, some SUV uptake in a fibrotic area in apex. Biopsy of this showed fibrosis and scant atypical cell. Cyberknife to mammary node, continue Tarceva. PET-10/13 – incr SUV to 14 in left primary tumor and new 1cm nodule in LUL, no new symptom. 12/13 – biopsy of LUL- same Exon 21, L858R – ?no T790M. on Tarceva 75/50. 1/14 PET – not much change. 2/14 – arm pain, cough, sob. CT – inc tumor to 5.5×5.9 with LUL collapse. 2/14 – Carbo/Pem x6. 4/14 PET – dec SUV but new bony lesions. PET in 6/14 – stable. start Pem every 3 wks in 7/14, Pamidronate every 6 wk.

May 14, 2014 at 7:21 pm  #1263762    
Dr West
Dr West

I’ve seen a few similar reports of planned collaborations, so let’s hope this is the way of the future.

-Dr. West

May 15, 2014 at 1:20 pm  #1263776    

Dr. Ben Creelan

It seems like more of an ongoing partnership than a collaboration, since Medarex (aka Celldex) originally developed nivolumab (aka Medarex-1106).

May 15, 2014 at 5:49 pm  #1263780    
Dr West
Dr West

Ah, yes, that’s true. I didn’t realize that Celldex was Medarex. I know a scientist who worked at Medarex and is very gratified that the agents he worked on before they reached people are now offering so much benefit to actual cancer patients.

-Dr. West

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