Can a smoking mother lead to a child developing NSCLC at age 47?

Portal Forums Lung/Thoracic Cancer Screening / Prevention Can a smoking mother lead to a child developing NSCLC at age 47?

This topic contains 3 replies, has 3 voices, and was last updated by catdander forum moderator catdander forum moderator 2 years, 4 months ago.

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April 9, 2016 at 12:15 pm  #1273552    


Is there any research that relates a mother smoking while pregnant to the development of NSCLC with ROS1 rearrangement at 47 yo?

April 10, 2016 at 6:04 am  #1273560    
JimC Forum Moderator
JimC Forum Moderator

Hi teddy,

I don’t know of any such research, and it’s unlikely that it’s been done or will be done, since the ROS1 rearrangement is mainly found in non-smokers. In addition, although smoking during pregnancy can pass toxins to the fetus, that would not be the same as the damage to the lungs caused by smoking itself (leading to the mutations that cause lung cancer). Certainly a child exposed to tobacco smoke has a greater risk of developing lung cancer, but probably not with the ROS1 rearrangement.

Forum moderator

Jul 2008 Wife Liz (51/never smoker) Dx Stage IV NSCLC EGFR exon 19
4 cycles Carbo/alimta, 65% shrinkage
Tarceva maintenance
Mar 2010 progression, added Alimta, stable
Sep 2010 multiple brain mets, WBR
Oct 2010 large pericardial effusion, tamponade
Jan 2011 progression, start abraxane
Jun 2011-New liver, brain mets, add Tarceva
Oct 2011-Dx Leptomeningeal carcinomatosis; pulsed Tarceva
At rest Nov 4 2011
Since then:

April 11, 2016 at 4:17 pm  #1273573    


Are there any studies in the scientific literature relating the development of NSCLC adenocarcinoma with ROS1 rearrangement of never smokers around age 50 to predisposition caused either through heredity or exposures during fetal development?

April 11, 2016 at 7:13 pm  #1273576    
catdander forum moderator
catdander forum moderator


I’m not sure how your 2nd question is different than your first.


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