I don’t know of any such research, and it’s unlikely that it’s been done or will be done, since the ROS1 rearrangement is mainly found in non-smokers. In addition, although smoking during pregnancy can pass toxins to the fetus, that would not be the same as the damage to the lungs caused by smoking itself (leading to the mutations that cause lung cancer). Certainly a child exposed to tobacco smoke has a greater risk of developing lung cancer, but probably not with the ROS1 rearrangement.
Jul 2008 Wife Liz (51/never smoker) Dx Stage IV NSCLC EGFR exon 19
4 cycles Carbo/alimta, 65% shrinkage
Mar 2010 progression, added Alimta, stable
Sep 2010 multiple brain mets, WBR
Oct 2010 large pericardial effusion, tamponade
Jan 2011 progression, start abraxane
Jun 2011-New liver, brain mets, add Tarceva
Oct 2011-Dx Leptomeningeal carcinomatosis; pulsed Tarceva
At rest Nov 4 2011
Since then: http://cancergrace.org/blog/jim-and-lisa
Are there any studies in the scientific literature relating the development of NSCLC adenocarcinoma with ROS1 rearrangement of never smokers around age 50 to predisposition caused either through heredity or exposures during fetal development?