Flu and chemo

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January 10, 2018 at 5:57 am  #1293745    



I was sick recently and I think that was flu. I took care of my dad up until the day I felt very sick. I am afraid I may pass the flu virus to him. He is now coughing a lot (other symptoms are slight high body temperature 98.9F sometimes, chest congestion with mucus). I called his PCP. She prescribe tamiflu and azithromycin.

I would like to know if it is okay to take tamiflu and azithromycin as prevention. While on chemo. He is going to have chemo tomorrow and continue for three days.


Diagnosed in 2014 stage 4 nsclc. EGFR+ (also positive for t790m). 1 year on Tarceva, then 8 months on Rociletinib, then WBR following by 7 months on Tarcrva pulse/carboplatin/avastin/alimta, then 7 month on Tagrisso. Was diagnosed leptomeningeal metastasis Nov 2015. Now has 10cm big tumor and multiple nodules with different sizes. Most recent guardant test (Feb 2017): TP53 C277F 29.8  EGFR Exon 19 Deletion 20.1  EGFR AMP ++  MET H1112Y 0.1  MET AMP +  FGFR1 AMP ++  PIK3CA AMP +  CCNE1 AMP ++  BRAF AMP +  MYC AMP ++  Additional Alterations  BRCA1 R7C 0.3  MTOR K1197E 0.2  NF1 V1762V 0.2  MET E436K 0.1  JAK2 V617F ND  MAP2K2 E66K ND. Dec 2017 liver biopsy reports my egfr non small cell lung cancer got mutated and changed to small cell lung cancer.

January 10, 2018 at 11:58 am  #1293749    
catdander forum moderator
catdander forum moderator

Hi Kkh,

I’m sorry your dad is feeling bad. It’s important to let his oncologist know of new or worsening symptoms and let her/him make decisions of what drugs to mix while on chemotherapy.

It’s more normal to take a flu and pneumonia vaccine as preventative measures. Oncologists often recommend these to their patients who are or will be on chemotherapy. Tamiflu is given to those who have flu and sometimes as a prophylactic. There are drug interactions and your dad’s oncologist would need to make the decision on whether to give chemo while on tamiflu.
Azithromycin is an antibiotic with many drug interactions. It is sometimes used as a prophylactic but too would need to be OK’d by his oncologist before taking chemotherapy.

I hope he is feeling better soon.

BTW, I wonder what clinical trials may be available to him (as a next option) given his genomic testing. For example MET inhibitors are looking very good for some MET Amp people with nsclc. If you’ve not seen the coverage here is a link to some of the presentations given at the recent targeted therapy conference in Cleveland.


All best,

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