Immunotherapy and tumor marker numbers

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This topic contains 2 replies, has 2 voices, and was last updated by  rayna 4 months, 3 weeks ago.

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June 29, 2017 at 3:14 pm  #1290942    

rayna

When just starting immunotherapy, for those who track tumor markers even in nsclc, do the numbers increase initially like how the tumors can initially swell?

June 29, 2017 at 9:45 pm  #1290946    
JimC Forum Moderator
JimC Forum Moderator

Hi rayna,

Welcome to GRACE. Since tumor markers really don’t reliably predict what is going on with an existing lung cancer, it’s not possible to make a generalization about whether a rising tumor marker at the beginning of immunotherapy indicates either progression or the pseudo-progression to which you refer. As such, if you’re dealing with the type of situation you describe, I would not make any assumptions about the efficacy of the immunotherapy.

JimC
Forum moderator


Jul 2008 Wife Liz (51/never smoker) Dx Stage IV NSCLC EGFR exon 19
4 cycles Carbo/alimta, 65% shrinkage
Tarceva maintenance
Mar 2010 progression, added Alimta, stable
Sep 2010 multiple brain mets, WBR
Oct 2010 large pericardial effusion, tamponade
Jan 2011 progression, start abraxane
Jun 2011-New liver, brain mets, add Tarceva
Oct 2011-Dx Leptomeningeal carcinomatosis; pulsed Tarceva
At rest Nov 4 2011
Since then: http://cancergrace.org/blog/jim-and-lisa

June 30, 2017 at 12:47 pm  #1290951    

rayna

thank you

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