Immunotherapy when tumor invades the pulmonary artery?

Portal Forums Cancer Treatments / Symptom Management Immune-based Therapy / Vaccines Immunotherapy when tumor invades the pulmonary artery?

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May 9, 2018 at 11:25 pm  #1294391    


My 74 year old mom was diagnosed with small cell lung cancer in September 2017 and she has been on chemotherapy since then. The main tumor is invading the pulmonary artery. She is in pretty Good condition so far and hasn’t had man side effects from the chemo so far.

Could immunotherapy (opdivo/yervoy) be an option even though the tumor is invading the pulmonary artery? Or are there bigger risks associated with treatment with immunotherapy than with regular chemotherapy when the tumor is growing into the artery?


May 10, 2018 at 8:10 am  #1294394    
JimC Forum Moderator
JimC Forum Moderator

Hi johanna,

Welcome to GRACE. I am sorry to hear of your mom’s diagnosis. Generally SCLC is treated with chemotherapy, and immunotherapy would likely be considered only if her cancer tested positive for high PD-L1 expression. Otherwise a change to a different chemotherapy regimen would be the typical choice if there is disease progression.

As far as increased risk of side effects with respect to the pulmonary artery invasion, I’m not aware of any information suggesting that. Dr. West discussed the typical side effects of immunotherapy here.

Good luck to your mom with future therapy.

Forum moderator

Jul 2008 Wife Liz (51/never smoker) Dx Stage IV NSCLC EGFR exon 19
4 cycles Carbo/alimta, 65% shrinkage
Tarceva maintenance
Mar 2010 progression, added Alimta, stable
Sep 2010 multiple brain mets, WBR
Oct 2010 large pericardial effusion, tamponade
Jan 2011 progression, start abraxane
Jun 2011-New liver, brain mets, add Tarceva
Oct 2011-Dx Leptomeningeal carcinomatosis; pulsed Tarceva
At rest Nov 4 2011
Since then:

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