interaction of steroids and targeted therapies

Portal Forums Cancer Treatments / Symptom Management General Treatments / Symptom Mgmt. interaction of steroids and targeted therapies

This topic contains 3 replies, has 3 voices, and was last updated by  tuliptime 2 years, 1 month ago.

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September 21, 2015 at 7:42 pm  #1271206    

kempten

Hello,
I came across a study that claimed that corticosteroids can interfere with the apoptosis effect of cancer drugs depending on the cancers genetics.
It said there is a surprising scarcity of high level data to support many of the common practices of clinicians treating brain tumor patients with steroids including overall indication, dosage and duration of therapy, the ubiquitous effects of the agents, as well as their mechanisms of action raise the question of interaction of steroids with the plethora of targeted therapies that are being developed for treatment of brain tumors.

Corticosteroids in brain cancer patients:
benefits and pitfalls ( 2011 )

I will need to take dexamethasone for a certain period of time after stereotactic radiation surgery for 3 small brain mets. Will I compromise Tarceva’s effectiveness??
Thank you for any enlightenment on this issue
Kempten

September 22, 2015 at 7:49 am  #1271209    
JimC Forum Moderator
JimC Forum Moderator

Hi Kempten,

That’s an interesting discussion you cite, which can be found here for those interested in reading it.

I think the best that can be said is that the research into the effect corticosteroids may have on cancer treatments is in its infancy. In the meantime, it is certainly well established that these steroids are very effective in reducing the symptoms of brain metastases, and remain the drug of choice in that context.

Knowledge regarding cancer and its treatments is constantly evolving, and at times patients and doctors face questions and make decisions before all the data is available, doing the best they can to make appropriate choices. In your situation, you may want to suggest to your doctor that you prefer the most minimal course of steroids which will still be effective in managing your brain mets.

Good luck.

JimC
Forum moderator


Jul 2008 Wife Liz (51/never smoker) Dx Stage IV NSCLC EGFR exon 19
4 cycles Carbo/alimta, 65% shrinkage
Tarceva maintenance
Mar 2010 progression, added Alimta, stable
Sep 2010 multiple brain mets, WBR
Oct 2010 large pericardial effusion, tamponade
Jan 2011 progression, start abraxane
Jun 2011-New liver, brain mets, add Tarceva
Oct 2011-Dx Leptomeningeal carcinomatosis; pulsed Tarceva
At rest Nov 4 2011
Since then: http://cancergrace.org/blog/jim-and-lisa

September 22, 2015 at 7:16 pm  #1271223    

kempten

Thank you Jim for your reply.
It helped me get some perspective
Kempten

October 7, 2015 at 4:10 am  #1271408    

tuliptime

I have read the same thing and steroids scare me.

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