keytruda, carboplatin, pemetrexed combo

Portal Forums Lung/Thoracic Cancer NSCLC Stage IV NSCLC keytruda, carboplatin, pemetrexed combo

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May 3, 2018 at 8:48 pm  #1294372    

sch1979

My father has an EGFR exon 20 insertion mutation. We found out today that the PD-L1 was 60% which apparently is rare for an exon 20 insertion, but it means immunotherapy is an option. The treatment plan right now is keytruda, carboplatin, pemetrexed. Has anyone had this combination?

May 4, 2018 at 5:27 am  #1294373    
JimC Forum Moderator
JimC Forum Moderator

Hi sch1979,

Since high PD-L1 expression is unusual for an exon 20 patient, there isn’t specific data on the efficacy of this immunotherapy/chemo combination, but the early trial results were so good they led to FDA provisional approval: http://cancergrace.org/lung/2017/07/25/why-carboplatin-pemetrexed-and-pembrolizumab-has-become-my-new-go-to-regimen-for-first-line-non-squamous-nsclc-treatment/

Another discussion of this combination therapy can be found here: http://cancergrace.org/lung/tag/keytruda/

I hope your father has great results with this regimen.

JimC
Forum moderator


Jul 2008 Wife Liz (51/never smoker) Dx Stage IV NSCLC EGFR exon 19
4 cycles Carbo/alimta, 65% shrinkage
Tarceva maintenance
Mar 2010 progression, added Alimta, stable
Sep 2010 multiple brain mets, WBR
Oct 2010 large pericardial effusion, tamponade
Jan 2011 progression, start abraxane
Jun 2011-New liver, brain mets, add Tarceva
Oct 2011-Dx Leptomeningeal carcinomatosis; pulsed Tarceva
At rest Nov 4 2011
Since then: http://cancergrace.org/blog/jim-and-lisa

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