low dose radiation with or without tarseva NSCA

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July 10, 2015 at 3:18 pm  #1270454    


On tarseva 1 year stage 4 NSCLC, recent progression of lesions. Is it best to stop Tarseva while receiving
low dose radiation? Thank you

July 11, 2015 at 9:16 am  #1270457    
JimC Forum Moderator
JimC Forum Moderator

Hi stash,

Although each situation is unique, in general oncologists seem to favor stopping Iressa/Tarceva during radiation since they can be radiosensitizers, increasing the effects of the radiation beyond what is desired or safe. As Dr. Weiss has said:

“I do not use tarceva concurrent with radiation in my practice. I fear safety issues, and also the potential for tarceva to keep cells out of cycle (not dividing) at time when radiation is being given (when you’d like them in cycle and therefor more susceptible to radiation).” -http://cancergrace.org/forums/index.php/topic,11108.msg90945.html#msg90945

In discussing trial results in which Iressa was combined with radiation, Dr. West stated:

“There really may be harmful interactions of EGFR inhibitors with radiation that we may not understand. I don’t think these results are clear enough to raise alarms, but it certainly suggests that we should be cautious about presuming that combining treatments is definitely a fine idea.”http://cancergrace.org/lung/2011/01/03/adding-egfr-inhibitor-therapy-to-radiation-or-chemoradiation-for-locally-advanced-nsclc/

Good luck with treatment.

Forum moderator

Jul 2008 Wife Liz (51/never smoker) Dx Stage IV NSCLC EGFR exon 19
4 cycles Carbo/alimta, 65% shrinkage
Tarceva maintenance
Mar 2010 progression, added Alimta, stable
Sep 2010 multiple brain mets, WBR
Oct 2010 large pericardial effusion, tamponade
Jan 2011 progression, start abraxane
Jun 2011-New liver, brain mets, add Tarceva
Oct 2011-Dx Leptomeningeal carcinomatosis; pulsed Tarceva
At rest Nov 4 2011
Since then: http://cancergrace.org/blog/jim-and-lisa

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