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April 29, 2015 at 1:41 pm  #1269401    


My father has stage IV adenocarcinoma, and is being offered a clinical trial with Lurbinectedin + Paclitaxel. Does anyone have experience with either of these drugs? I’m trying to get an idea of the potential efficacy of this combination so we can assess the risk. Another institution is proposing moving on to radiotherapy, but I’m not sure if this has the potential to be much more effective than that.


April 29, 2015 at 4:42 pm  #1269402    
JimC Forum Moderator
JimC Forum Moderator


Welcome to GRACE. There’s a trial of this sprt at Memorial Sloan Kettering in New York - It’s a Phase I trial, so although the trual sponsors believe it shows promise, it’s very early in the testing process and unknown how effective it will be.

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Jul 2008 Wife Liz (51/never smoker) Dx Stage IV NSCLC EGFR exon 19
4 cycles Carbo/alimta, 65% shrinkage
Tarceva maintenance
Mar 2010 progression, added Alimta, stable
Sep 2010 multiple brain mets, WBR
Oct 2010 large pericardial effusion, tamponade
Jan 2011 progression, start abraxane
Jun 2011-New liver, brain mets, add Tarceva
Oct 2011-Dx Leptomeningeal carcinomatosis; pulsed Tarceva
At rest Nov 4 2011
Since then:

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