Metatarsal stress fracture related to bone metasases, Xgeva, or cancer drugs?

Portal Forums Lung/Thoracic Cancer Lung Cancer Complications Bone Metastases Metatarsal stress fracture related to bone metasases, Xgeva, or cancer drugs?

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February 11, 2018 at 12:13 pm  #1293957    


Recent stress fracture in right 4th metatarsal bone. No traumatic event caused it. does not appear to be metastatic, though I have other bone mets in pelvic bone, ribs due to stage 4 ALK+ NSCLC. Wore a boot for 6 weeks but it did not heal. Have been on Zometa then Xgeva for past 6 years since diagnosis. Been on Brigatinib since July 2014. 2 years of maintenance Alimta before that and 4 rounds of taxol/carboplatin at the start of treatment. I know of possible jaw necrosis and femur fracture with bisphosphonates but has anyone heard of stress fracture? Or any reason why bone would not heal related to any of the above treatments?

February 11, 2018 at 4:55 pm  #1293959    
JimC Forum Moderator
JimC Forum Moderator

Hi sd2011,

I’m sorry to hear that your stress fracture is not healing. I have not found any mention of Xgeva or the other treatments causing stress fractures, or preventing them from healing, and it is not at all common for lung cancer to metastasize to metatarsals. Such metastases do not usually appear below the knees, although cancer seems capable of anything.

I wish I had a good suggestion for you, other than perhaps a second opinion from an orthopedist, but I hope you can find an answer soon.

Forum moderator

Jul 2008 Wife Liz (51/never smoker) Dx Stage IV NSCLC EGFR exon 19
4 cycles Carbo/alimta, 65% shrinkage
Tarceva maintenance
Mar 2010 progression, added Alimta, stable
Sep 2010 multiple brain mets, WBR
Oct 2010 large pericardial effusion, tamponade
Jan 2011 progression, start abraxane
Jun 2011-New liver, brain mets, add Tarceva
Oct 2011-Dx Leptomeningeal carcinomatosis; pulsed Tarceva
At rest Nov 4 2011
Since then:

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