Newly diagnosed with mesothelioma

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May 9, 2014 at 8:00 am  #1263677    


My husband was recently diagnosed with mesothelioma. He had his first chemo last Friday combination altima/cisplatin. He had severe burping the first night. The oncologist did not mention that as a possible side effect. That symptom seemed to ease after 3 days. He still gets waves of nausea and he is fatigued. How long can he expect to feel the side/after effects? His next treatment is scheduled for two weeks from today.

May 9, 2014 at 9:41 am  #1263678    
JimC Forum Moderator
JimC Forum Moderator

Hi sharonp,

It is not unusual to experience problems with nausea and vomiting after most types of chemo; the burping may just be a part of what’s going on in the digestive system. Each patient reacts differently, but for many the nausea subsides after a week or two. To help prevent it, he should try taking his anti-nausea meds on a schedule, rather than when he feels nauseous…it’s easier to prevent than it is to get rid of. Small, frequent meals are better than larger ones, and taking a walk can also help. If it persists, perhaps his doctor can prescribe a different anti-nausea medication.

Fatigue can occur as blood counts drop after chemo. They tend to rebound in the second half of the cycle, so hopefully he’ll start feeling a bit better soon.

Forum moderator

Jul 2008 Wife Liz (51/never smoker) Dx Stage IV NSCLC EGFR exon 19
4 cycles Carbo/alimta, 65% shrinkage
Tarceva maintenance
Mar 2010 progression, added Alimta, stable
Sep 2010 multiple brain mets, WBR
Oct 2010 large pericardial effusion, tamponade
Jan 2011 progression, start abraxane
Jun 2011-New liver, brain mets, add Tarceva
Oct 2011-Dx Leptomeningeal carcinomatosis; pulsed Tarceva
At rest Nov 4 2011
Since then:

May 9, 2014 at 5:49 pm  #1263683    


You can also ask his doctor about taking an OTC like Prilosec. Cisplatin can cause heartburn, so adding it along with the anti-nausea drug might help. But always check with is doctor first, though I took it with carbo/alimta and it helped. Take care, Judy

Stage IIIA adeno, dx 7/2010. SRS then chemo carbo/alimta 4x. NED as of 10/2011.
Local recurrence, surgery to remove LRL 8/29/13. 5.2cm involved pleura. Chemo carbo/alimta x3. NED

May 9, 2014 at 7:24 pm  #1263685    
Dr West
Dr West

I’m sorry he’s having a tough time.

Though every patient is different, it’s most common for people to really turn a corner right around now — 5 to 7 days after the chemo is given. Cisplatin-based chemo is notoriously challenging, sometimes leading to more severe and longer-lasting side effects than alternatives. Cisplatin with Alimta (pemetrexed) is the best studied, clear standard of care chemo combination for mesothelioma, but there is also evidence that substituting the less challenging carboplatin for cisplatin can lead to very comparable efficacy results:.

Good luck.

-Dr. West

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