Opdivo and Yervoy trial

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April 19, 2018 at 3:17 pm  #1294275    


Stage lV Adenocarcinoma with Efgr and 80% pdl1

Had 5 radiation treatments to lung prior to start of trial. Received 4 treatments of drugs opdivo and Yervoy for trial and latest CT of chest results were:
Worsening interlobular septal thickening and nodularity.
Suprahilar right upper lobe mass is no longer definitively visualized but there are new
increased areas of consolidation in the central aspect of the right middle lobe and right
lower lobe demonstrating mass effect on the right lower lobe bronchus.
Any suggestions of what is going on with treatment working or not? Dr wants a bronchoscope done to check things out.
Very confused…

April 20, 2018 at 6:10 am  #1294277    
JimC Forum Moderator
JimC Forum Moderator

Hi cal4da31,

Welcome to GRACE. Although your own doctors would be in the best position to interpret your scan results, it appears that you may be having a “mixed response” to treatment, where some areas if cancer may be improving while others are growing. But the statements in the scan report don’t clearly describe progression, which is why your doctor wants to investigate further.

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Jul 2008 Wife Liz (51/never smoker) Dx Stage IV NSCLC EGFR exon 19
4 cycles Carbo/alimta, 65% shrinkage
Tarceva maintenance
Mar 2010 progression, added Alimta, stable
Sep 2010 multiple brain mets, WBR
Oct 2010 large pericardial effusion, tamponade
Jan 2011 progression, start abraxane
Jun 2011-New liver, brain mets, add Tarceva
Oct 2011-Dx Leptomeningeal carcinomatosis; pulsed Tarceva
At rest Nov 4 2011
Since then: http://cancergrace.org/blog/jim-and-lisa

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