Relationship between anti-depressant use and lung cancer survival

Portal Forums Lung/Thoracic Cancer General Lung/Thoracic Cancer Relationship between anti-depressant use and lung cancer survival

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April 8, 2018 at 2:55 pm  #1294191    

onthemark

The article linked below suggests that using specific types of anti-depressants (tricyclic and NDRI’s) increases survival in lung cancer in both clinically and statistically significant ways. No benefit is seen with SSRI’s however.

NDRI means norepinephrine and dopamine reuptake inhibitors, one of which is Wellbutrin, which happens to be a medication I have been taking now for about half a year. It seems like a really easy thing to try to extend survival so I thought maybe other people here would be interested.

The article is freely available at:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5603309/


10/2015 Chest xray found a nodule as part of a physical (no symptoms).
01/2016 Upper left lobe lingula preserving lobectomy stage 2b for 1.9 cm invasive adenocarcinoma with additional 2 mm AIS nodule found in pathology.
03-05/2016 Sixteen weeks of adjuvant cisplatin/vinorelbine.
07/2016 Durvalumab adjuvant clinical trial discontinued after 1st dose knocked out thyroid.
12/2016 Revised to stage 1b (due to VPI) after new guidelines for multifocal lepidic lung cancer.
07/2018 Next scan.

April 9, 2018 at 7:02 am  #1294193    
JimC Forum Moderator
JimC Forum Moderator

Hi onthemark,

Thanks for sharing that very interesting study, which may be helpful to our other members. Any additional weapons in the fight against lung cancer are certainly of interest!

JimC
Forum moderator


Jul 2008 Wife Liz (51/never smoker) Dx Stage IV NSCLC EGFR exon 19
4 cycles Carbo/alimta, 65% shrinkage
Tarceva maintenance
Mar 2010 progression, added Alimta, stable
Sep 2010 multiple brain mets, WBR
Oct 2010 large pericardial effusion, tamponade
Jan 2011 progression, start abraxane
Jun 2011-New liver, brain mets, add Tarceva
Oct 2011-Dx Leptomeningeal carcinomatosis; pulsed Tarceva
At rest Nov 4 2011
Since then: http://cancergrace.org/blog/jim-and-lisa

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