Sarcomatoid carcinoma lungs

Portal Forums Lung/Thoracic Cancer General Lung/Thoracic Cancer Sarcomatoid carcinoma lungs

This topic contains 3 replies, has 2 voices, and was last updated by  ol33 4 months, 1 week ago.

Viewing 4 posts - 1 through 4 (of 4 total)
Author Posts   
Author Posts
July 29, 2017 at 11:42 pm  #1291144    

ol33

My mother-in-law was just diagnosed with sarcomatoid carcinoma of lungs. We would like to get a second opinion. Any suggestions as to who is an authority or has experience with this condition/diagnosis? Thank you so much for all and any help. Seems like finding an expert for this condition is a bit more challenging…

July 30, 2017 at 8:14 am  #1291146    
JimC Forum Moderator
JimC Forum Moderator

Hi ol33,

Welcome to GRACE. I’m sorry to hear of your mother-in-law’s diagnosis, and the difficulty she is having in locating an expert in this particular cancer. My best suggestion to find such an expert would be to look at publications listed on PubMed and looking to see who has published on this subject. You can start with these search results for “pulmonary AND sarcomatoid AND carcinoma”: https://www.ncbi.nlm.nih.gov/pubmed/?term=pulmonary+AND+sarcomatoid+AND+carcinoma You can also try adding “AND Chicago” (or other location), but that will only return results for that specifically named place. An institution in suburban Chicago would not appear, nor would one within a reasonable driving distance.

Click on a publication in the list that contains those terms, then click on “author information” which appears below the name of the article and the names of the authors. The superscript after each author’s name will be referenced in the information, so you can see the institution with which the author is affiliated. I’m afraid it’s a bit of a time-consuming process, but as you say it can be difficult to find doctors who have experience in such an uncommon diagnosis.

Good luck.

JimC
Forum moderator


Jul 2008 Wife Liz (51/never smoker) Dx Stage IV NSCLC EGFR exon 19
4 cycles Carbo/alimta, 65% shrinkage
Tarceva maintenance
Mar 2010 progression, added Alimta, stable
Sep 2010 multiple brain mets, WBR
Oct 2010 large pericardial effusion, tamponade
Jan 2011 progression, start abraxane
Jun 2011-New liver, brain mets, add Tarceva
Oct 2011-Dx Leptomeningeal carcinomatosis; pulsed Tarceva
At rest Nov 4 2011
Since then: http://cancergrace.org/blog/jim-and-lisa

July 30, 2017 at 8:23 am  #1291147    
JimC Forum Moderator
JimC Forum Moderator

ol33,

You might also want to search for clinical trials at clinicaltrials.gov using the same search criteria.

We don’t have an expert on this subject on GRACE, but Dr. West had this to say about treatment options (although is comments were in the context of maintenance, they would be relevant to any systemic treatment options for sarcomatoid carcinoma):

“I’m sorry that I think you’re very unlikely to have anyone here who can comment on what to expect for sarcomatoid histology, since it’s so rare. Aside from the promising results in a few patients with this histology who received immunotherapies like anti-PD1 agents, there’s really no specific information about it.

Taxol (paclitaxel) is not commonly used as a maintenance therapy, since it has no proven value after 4-6 cycles and definitely leads to cumulative neuropathy.

Avastin (bevacizumab) alone is sometimes used, and it is the more studied approach after carboplatin/taxol/Avastin as first line therapy.

The hesitation about Alimta (pemetrexed) is understandable, since it definitely has some specificity for non-squamous histology and may not have activity in sarcomatoid histology…that’s just not known.

Otherwise, Tarceva (erlotinib) and Taxotere (docetaxel) have each been studied as a maintenance therapy and have some evidence for potential benefit as well. That said, there’s no established best approach in this situation.”http://cancergrace.org/topic/sarcomatoid-carcinoma-maintenance#post-1259405

JimC
Forum moderator


Jul 2008 Wife Liz (51/never smoker) Dx Stage IV NSCLC EGFR exon 19
4 cycles Carbo/alimta, 65% shrinkage
Tarceva maintenance
Mar 2010 progression, added Alimta, stable
Sep 2010 multiple brain mets, WBR
Oct 2010 large pericardial effusion, tamponade
Jan 2011 progression, start abraxane
Jun 2011-New liver, brain mets, add Tarceva
Oct 2011-Dx Leptomeningeal carcinomatosis; pulsed Tarceva
At rest Nov 4 2011
Since then: http://cancergrace.org/blog/jim-and-lisa

July 30, 2017 at 11:44 pm  #1291150    

ol33

Dear JimC,
Thank you so much! It is very helpful. I was actually using this approach with the google search – with not much progress or result. I will definitely try PubMed.
Once again, thank you for this helpful pointer and all the best.
ol33

Viewing 4 posts - 1 through 4 (of 4 total)

You must be logged in to reply to this topic.