TAK-788 Trial

This topic contains 2 replies, has 3 voices, and was last updated by  onthemark 5 days, 8 hours ago.

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August 8, 2018 at 6:48 pm  #1295011    

scohn

Well, here we are, barring any last minute complications my wife should start the TAK-788 trial next week. She has already had her main blood work and a CT scan. All she needs now is an updated brain MRI and a blood test for magnesium and bilirubin.

The trial oncologist sounded very optimistic, and said they were having good success with the drug so far (as Jim posted with the ASCO results). Main side effects so far have apparently been diarrhea and an acne-like rash (especially for people who spend time in the sun). And no steroids! So hopefully less sleepless nights and a bit less heartburn (although you can’t take any acid reducers on this trial, probably worried about effects on drug uptake since it is a pill). It’s a small molecule TKI, designed to bind more tightly to the Exon20 mutations than to the normal EGFR or HER2. And apparently the EGFR cohort for the trial is full, but they need more HER2 patients, so my wife is once more plunging in to help science!

So onward we go – treatment line #5. I’ll update after next week (for first day of trial my wife has to spend all day at U of C – the drug in the morning and blood draws every hour to measure release of drug into bloodstream).


Wife, lifelong non-smoker, dx 4/24/15 adeno NSCLC stage IV-2 bone mets, 1 lymph node. HER2 Exon 20 mutation. 6x Carbo/Alimta – >50% reduction in primary tumor, lymph nodes, & bone. Alimta maint. not effective -growth & new liver mets. 11/15 – Opdivo; Not effective-add’l growth. 4/16 – PF-7020- large reduction of tumor and mets. 11/16-mixed results, liver mets stable. 2/17-All Stable. 8/17- Add’l growth-off Pfizer trial, 9/17 Gemzar- reduction then stable. 8/18 – Mixed results – new treatment?

August 9, 2018 at 7:23 am  #1295013    
catdander forum moderator
catdander forum moderator

Scohn,

I’m hopeful that your wife will respond well to tak 788. Let us know when y’all find some names for it.

Fingers crossed,
Janine

August 9, 2018 at 7:59 am  #1295014    

onthemark

scohn,

It’s wonderful that your wife has the chance to take part in this trial and I hope you see terrific results!


10/2015 Chest xray found a nodule as part of a physical (no symptoms).
01/2016 Upper left lobe lingula preserving lobectomy stage 2b for 1.9 cm invasive adenocarcinoma with additional 2 mm AIS nodule found in pathology.
03-05/2016 Sixteen weeks of adjuvant cisplatin/vinorelbine.
07/2016 Durvalumab adjuvant clinical trial discontinued after 1st dose knocked out thyroid.
12/2016 Revised to stage 1b (due to VPI) after new guidelines for multifocal lepidic lung cancer.
07/2019 Next scan.

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