Timing of the Tarceva dose

Portal Forums Cancer Treatments / Symptom Management EGFR Inhibitors Timing of the Tarceva dose

This topic contains 5 replies, has 3 voices, and was last updated by JimC Forum Moderator JimC Forum Moderator 4 months, 2 weeks ago.

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March 30, 2017 at 6:57 pm  #1290480    

jkcath

In tracking my wife diarrrhea with Tarceva we found that 70% of the time it hits in the morning. This jumps to to about 90% plus for the unexplained diarrhea episodes that cannot be traced to a trigger food or an event such as overeating. She take the Tarceva between 10 and 10:30pm, she eats very lightly at breakfast and the rest of the morning. We tend to be morning people while we can work around this at home it really wrecks our traveling. Is it possible that changing the timing of the Tarceva could move the prime diarrhea worry time to the evening?

March 31, 2017 at 2:54 pm  #1290488    
catdander forum moderator
catdander forum moderator

Yes jkcath it’s possible and certainly worth trying. I remember when my husband took tarceva he had a tough time with diarrhea. Talk to your oncology team about it but unless she skips around a lot with the timing I don’t think it would be a problem to test out a different pattern.

Best of luck,
Janine

April 1, 2017 at 1:07 pm  #1290491    

jkcath

I think we will give this a go, I do not see much down side other than getting comfortable with a new schedule. Not sure if the diarrhea issues are timing or what.

April 2, 2017 at 7:50 am  #1290497    
JimC Forum Moderator
JimC Forum Moderator

I’d agree that it’s worth trying. Every person has his/her own pattern of bowel regularity, so fitting the timing of the Tarceva dosage into your wife’s pattern may help quite a bit.

Good luck getting the problem under more manageable control.

JimC
Forum moderator


Jul 2008 Wife Liz (51/never smoker) Dx Stage IV NSCLC EGFR exon 19
4 cycles Carbo/alimta, 65% shrinkage
Tarceva maintenance
Mar 2010 progression, added Alimta, stable
Sep 2010 multiple brain mets, WBR
Oct 2010 large pericardial effusion, tamponade
Jan 2011 progression, start abraxane
Jun 2011-New liver, brain mets, add Tarceva
Oct 2011-Dx Leptomeningeal carcinomatosis; pulsed Tarceva
At rest Nov 4 2011
Since then: http://cancergrace.org/blog/jim-and-lisa

April 3, 2017 at 2:25 pm  #1290503    

jkcath

When she take Tarceva at 10 – 10:30PM we find that she can only eat a very small breakfast around 7:30 AM and can only eat one or two tiny snacks before noon.

If we switch the Tarceva to 6 AM would she have to eat very tiny portions for the next 12-14 hours or would this change if she ate about an hour after taking the Tarceva?

She tried to eat a graham cracker around 4 AM, but that seemed to throw the diarrhea off, it could occur any time between 9 AM and 11 AM when we were doing this, we stopped this since it seemed to make things worst.

Trying to avoid another failed effort for my wife.

Thanks

April 3, 2017 at 6:08 pm  #1290504    
JimC Forum Moderator
JimC Forum Moderator

Hi jkcath,

Unfortunately I don’t think it’s possible to predict with any certainty what may happen and when it may happen,other than by trial and error. I wish that there was a better answer, but in reviewing your previous threads, it seems as though you’ve tried all the typical interventions. Aside from switching to another type of treatment such as chemotherapy, I’m not sure what else can be recommended.

JimC
Forum moderator


Jul 2008 Wife Liz (51/never smoker) Dx Stage IV NSCLC EGFR exon 19
4 cycles Carbo/alimta, 65% shrinkage
Tarceva maintenance
Mar 2010 progression, added Alimta, stable
Sep 2010 multiple brain mets, WBR
Oct 2010 large pericardial effusion, tamponade
Jan 2011 progression, start abraxane
Jun 2011-New liver, brain mets, add Tarceva
Oct 2011-Dx Leptomeningeal carcinomatosis; pulsed Tarceva
At rest Nov 4 2011
Since then: http://cancergrace.org/blog/jim-and-lisa

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