TRF1 inhibitor

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May 14, 2015 at 2:27 am  #1269537    


Just found these interesting articles:

Is it really a promising therapy?

Father (72), no smoker.
4/09 suspicious nodule, upper left lobe.
7/09 lobectomy, 2cm adeno (T1N0M0). No adjuvant chemo.
1/10 found another nodule, lower left lobe (probably unnoticed in 2009).
4/10 completion pneumonectomy, 2cm adeno, 2 positive regional lymph nodes (T2N1M0). No adjuvant chemo.
9/10 PET-CT: negative.
4/11 PET-CT: positive lymph nodes (mediastinal, superclavear).
5/11 biopsy of 1 superclavear lymph node, adeno met, EGFR+ mutation.
6/11 start Iressa.
9/11 PET-CT: negative. Great response to Iressa.
2/12 PET-CT: negative.
7/12 PET-CT: positive lymph nodes (mediastinal, superclavear, axillary).
9/12 PET-CT: positive lymph nodes, higher SUV.
12/12 CT scan: 7.5mm and 3mm brain mets, multiple 3-4mm nodules in right lung, 10mm lesion in liver and osteolytic areas in the XI rib and L3 vertebra. Stop Iressa and switch to Taxotere.
4/13 CT scan: good response to Taxotere. After 5 cycles, only three 3mm nodules visible in liver, brain mets stable.
5/13 Taxotere no longer tolerated + dizziness, nausea, vomiting, aphasia, hearing loss (brain mets?). Start re-challenge with Tarceva (150mg per day). Significant improvement of physical conditions after only 2 weeks of treatment.
8/13 Tarceva seriously affecting kidney function. Dose reduced to 100mg every other day.
9/13 Sudden onset of neurological symptoms. CT scan shows 4 brain lesions (29mm, 28mm, 16mm, 15mm) with cerebral swelling + multiple micro nodules in right lung. WBR carried out (2000cGy over 5 fractions).
10/13 Significant physical and neurological decline soon after WBR. Only palliative care.
12/13 CT scan: all brain lesions disappeared (only one single 6mm nodule left), micro nodules in right lung significantly reduced (were they really cancer?). Still with significant neurological impairment, likely to be associated with radiation-induced necrosis. On palliative care only (dexamethasone + nimodipine)
02/14 Dad passed away peacefully on Feb 8th 2014.

May 14, 2015 at 9:12 am  #1269543    
JimC Forum Moderator
JimC Forum Moderator

Hi watu,

Since these studies are in mice, it’s really too early to tell. Many ideas look promising in the lab or in animal models but either never reach human trials or fail when they do. Of course, every successful idea starts somewhere, so the more avenues of research (such as this one) the better. Only time will tell whether this idea will turn into an actual therapy and succeed in human trials.

Forum moderator

Jul 2008 Wife Liz (51/never smoker) Dx Stage IV NSCLC EGFR exon 19
4 cycles Carbo/alimta, 65% shrinkage
Tarceva maintenance
Mar 2010 progression, added Alimta, stable
Sep 2010 multiple brain mets, WBR
Oct 2010 large pericardial effusion, tamponade
Jan 2011 progression, start abraxane
Jun 2011-New liver, brain mets, add Tarceva
Oct 2011-Dx Leptomeningeal carcinomatosis; pulsed Tarceva
At rest Nov 4 2011
Since then:

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