This topic contains 5 replies, has 3 voices, and was last updated by catdander forum moderator catdander forum moderator 8 months, 2 weeks ago.

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September 17, 2017 at 3:12 am  #1292416    


Im interested in knowing, whats the allowed growth of AST and ALT to stop using xalkori?

September 17, 2017 at 1:39 pm  #1292418    
catdander forum moderator
catdander forum moderator

From a previous post and still accurateDr. West states, “The dosing recommendations are that if the “transaminases”, which are listed as ALT and AST, are more than 5x the “upper limit of normal” (ULN) at that particular lab, and the bilirubin level is less than 1.5x ULN, then the dose should be reduced to 200 mg by mouth twice daily once the AST and ALT are less than 2.5x ULN. If the ALT and/or AST numbers are elevated and the bilirubin is higher than 1.5x ULN, the guidelines say to discontinue the drug.” http://cancergrace.org/topic/xalkori-side-effects#post-1246670

I hope you do well.
All best,

September 21, 2017 at 7:25 am  #1293145    


When the dose of pills xalkori is lowered, in how many days can liver enzymes get lower?

September 21, 2017 at 8:16 am  #1293146    
JimC Forum Moderator
JimC Forum Moderator

Hi dozivivise,

There’s really no way to put a time frame on it. As Dr. West has said:

“Obviously, the idea is to drop to a level where there is no elevation in the liver enzymes, or the level of elevation is limited enough that it isn’t a significant concern. Unfortunately, however, there’s no way to know in advance whether the lower dose will still lead to elevated liver enzymes or not. You just need to see what happens after trying it.”http://cancergrace.org/topic/xalkori-and-increased-liver-enzymes

I hope the dose reduction works well for you.

Forum moderator

Jul 2008 Wife Liz (51/never smoker) Dx Stage IV NSCLC EGFR exon 19
4 cycles Carbo/alimta, 65% shrinkage
Tarceva maintenance
Mar 2010 progression, added Alimta, stable
Sep 2010 multiple brain mets, WBR
Oct 2010 large pericardial effusion, tamponade
Jan 2011 progression, start abraxane
Jun 2011-New liver, brain mets, add Tarceva
Oct 2011-Dx Leptomeningeal carcinomatosis; pulsed Tarceva
At rest Nov 4 2011
Since then: http://cancergrace.org/blog/jim-and-lisa

October 1, 2017 at 1:30 am  #1293208    


Can i drink syrup of artichokes

October 1, 2017 at 12:43 pm  #1293209    
catdander forum moderator
catdander forum moderator

I think you’re asking if artichoke syrup has a lower glycemic index than other sugars and that is beyond the scope of Grace. I didn’t find any info that says anything other than suggests it would be better than other types of high fructose syrups and that was from those selling it.

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