Xalkori "maintenance"

This topic contains 4 replies, has 5 voices, and was last updated by JimC Forum Moderator JimC Forum Moderator 3 years, 5 months ago.

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February 12, 2012 at 11:31 am  #1241507    


All day today I was wondering; Am I now on xalkori as maintenance? I am stage 4 and have been NED from the neck down since june 2010. I have been dealing with brain mets since july 2011. I just had a clean scan for the brain and chest.
Since I am technically NED am I building up a resistance w/o actually having any visible tumors? Is there anybody else on xalkori who is NED? Maybe not actually having any tumors I can stay on xalkori longer than the stats. Is xalkori approved for maintenace? Of course if any brain tumors pop up I will have them zapped. Thanks, Sean

February 12, 2012 at 4:05 pm  #1241521    

double trouble

Hi Sean. Welcome. Grace has just transferred it’s entire site to a new home and we’re all learning how to navigate here, and bugs are being addressed during this roll out period. I’m sure the faculty will be along soon to answer your question. Meanwhile, I just wanted to say congratulations on being NED! We love hearing that! The doctor’s will be along soon to reply to your question.

February 12, 2012 at 5:31 pm  #1241524    
Dr West
Dr West


Agents like XALKORI (crizotinib) are meant to be taken in the setting of known advanced disease and then until the time of progression. You can say that it’s leading to the potential development of progression, but it’s also almost certainly actively suppressing the disease. While it may be possible to stop an agent like XALKORI or an EGFR inhibitor like Tarceva (erlotinib) or Iressa (gefitinib) after someone has achieved their best response, that isn’t how they have been studied, and there isn’t a lot of enthusiasm for stopping a treatment that is almost certainly the reason that the person is doing so well. There is even evidence that some people experience a rapid progression of their disease as a “rebound” effect after stopping the targeted therapy that has been very effective.

Please note that we’re not going to keep this generic “ASK US” section, since that’s pretty much a no-man’s land for the forums, and instead will ask people to identify the most appropriate subject for their question.

-Dr. West

February 27, 2015 at 9:44 pm  #1268690    


does your site deal with questions about cll and its treatment?


February 28, 2015 at 7:30 am  #1268693    
JimC Forum Moderator
JimC Forum Moderator

Hi bella,

Unfortunately, at this time GRACE does not have a faculty member who focuses on leukemias and lymphomas such as CLL.

Forum moderator

Jul 2008 Wife Liz (51/never smoker) Dx Stage IV NSCLC EGFR exon 19
4 cycles Carbo/alimta, 65% shrinkage
Tarceva maintenance
Mar 2010 progression, added Alimta, stable
Sep 2010 multiple brain mets, WBR
Oct 2010 large pericardial effusion, tamponade
Jan 2011 progression, start abraxane
Jun 2011-New liver, brain mets, add Tarceva
Oct 2011-Dx Leptomeningeal carcinomatosis; pulsed Tarceva
At rest Nov 4 2011
Since then: http://cancergrace.org/blog/jim-and-lisa

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