Enhertu Not Working?

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scohn
Enhertu Not Working?

Looks like enhertu is not working?  Had blood tests today - Bilirubin is way up.  Hemoglobin down so my wife is getting another transfusion.

Her fatigue has been extreme these last few days.

Noun loss is getting worse, but we don't know if it is stress, brain function, or liver function.

 

She is getting new blood tests on Friday - we will let you know more then.

 

JanineT Forum M...
Enhertu working?

I'm sorry Scohn, I know this isn't what we want to hear.  I hope the transfusion will help with her fatigue and noun loss.  As someone who has always lived with word loss, fatigue makes mine a lot worse.  I will hope that enhertu just hasn't started showing its benefits just yet. 

Keeping you and her in my thoughts.

Janine

Jim C Forum Mod...
Jim C Forum Moderator's picture
Enhertu working?

I'm sorry to hear this scohn, but will join in Janine's hope that Enhertu has not yet had sufficient time to produce a benefit (certainly not unusual). We'll remain hopeful that it will display efficacy soon, and look forward to hearing some better news in your next update.

 

Jim C Forum Moderator 

 

scohn
Enhertu Is Working?

Well, my wife has now had her 2nd Enhertu treatment, and the blood tests prior to the treatment suggest it might be starting to work.  If so, it looks like Enhertu is a slower, gentler, kind of treatment.  Her bilirubin, SGOT, and SGPT were down by about half, and her ALK was down about 30%.  She still has considerable edema in her legs, which the doctor thinks is because her protein and albumin are still low.  Put her on Lasix and compression stockings.

 

So, it looks like it might be starting to work, but we will know more with her first post-Enhertu CT scan in 3 weeks.

 

In the meantime, our anniversary in 2 weeks, followed by the 1st birthday of our grandson the following day!

Wife, non-smoker, dx 4/24/15 adeno NSCLC stage IV. HER2 Exon 20. 6/15 6x Carbo/Alimta; effective. 9/15 Alimta maint; ineffect. 11/15 - Opdivo; ineffect. 4/16 - ptK7 trial; effective 1.5 yr. 9/17 Gemzar; effective 16 mo. 8/18 -TAK788 Trial; ineffective. 10/18 Abraxane; effective. 7/19 Kadcyla; effective. 10/19 Carbo/Alimta/Keytruda followed by Alimta; ineffective. 4/20-Poziotinib; effective. 7/20 - Enhertu;?

JanineT Forum M...
Hi Scohn, That's (cautiously)

Hi Scohn,

 

That's (cautiously) very hopeful news!  So happy your family is celebrating 2 excellent anniversaries.  I'm keeping fingers crossed she continues to improve and edema calms. 

 

Cheers,

Janine