GRACE :: Global Resource for Advancing Cancer Education
  • Recent GRACE News & Posts

    • Clinical Trial Spotlight: Identifying Lung Cancer Patients Who Respond to Ponatinib [GRACE :: Lung Cancer]
      Dr. Ross Camidge discusses a clinical trial studying patients with advanced stage lung cancer to identify those who may respond to a drug called ponatinib. Both small cell and non small cell lung cancer patients may be eligible.
    • Postcards from Her Patients [GRACE :: Lung Cancer]
      Dr. Seema Nagpal insists on one thing from her lung cancer patients: Proof that they are enjoying their lives. November is Lung Cancer Awareness Month. What are you grateful for?
    • Clinical Trial Spotlight: Options for EGFR Mutation-Positive Patients with T790M Mutation-Negative Acquired Resistance [GRACE :: Lung Cancer]
      Dr. Jack West reviews treatment options for patients with an EGFR activating mutation and acquired resistance but no T790M mutation, focusing on a clinical trial with the novel hypoxia-induced pan-HER inhibitor TH4000.
    • Clinical Trials of Immune Checkpoint Inhibitors as First Line Therapy for Advanced NSCLC [GRACE :: Lung Cancer]
      Dr. Jack West summarizes the rationale for testing immune checkpoint inhibitors as a first line treatment for patients with advanced NSCLC and highlights details of two trials testing this question.
    • What is the Current Role of Serum Based Biomarker Testing? [GRACE :: Lung Cancer]
      Drs. Ben Solomon, Leora Horn, & Jack West assess the utility and limitations of "liquid biopsies", serum-based testing for molecular marker testing in lung cancer.
    • Gratitude [GRACE :: Lung Cancer]
      In this month of gratitude, we have asked many people to share themselves with GRACE and our community. We usually do the asking -- but Carlea asked me this time to share my thoughts of gratitude. Sometimes writing these things is a struggle.
    • Many Clinical Trial Options Exist for Small Cell Lung Cancer Patients [GRACE :: Lung Cancer]
      Guest post by Dr. Cathy Pietanza, a board-certified medical oncologist at Memorial Sloan Kettering Cancer Center in New York. She specializes in cancers that arise in the lungs and cares for a large number of patients with small cell lung cancer (SCLC).
    • Should Immune Checkpoint Inhibitors and Other Therapies Be Combined Concurrently or Sequentially? [GRACE :: Lung Cancer]
      Drs. Leora Horn, Ben Solomon, & Jack West consider the merits of administering immune checkpoint inhibitors concurrently with standard first line chemotherapy or targeted therapy vs. sequential treatment.
    • Clinical Trial Spotlight: Should a Second Generation ALK Inhibitor be First Line Therapy for Patients with ALK-Positive NSCLC? [GRACE :: Lung Cancer]
      Dr. Jack West asks the question of whether newer, more active ALK inhibitors such as alectinib should be used as first line therapy rather than for acquired resistance, including introducing the ALEX trial that is trying to answer this question.
    • Are Immune Checkpoint Inhibitors Sufficiently Tolerable to Recommend Them for Older or More Frail Patients? [GRACE :: Lung Cancer]
      Drs. Ben Solomon, Leora Horn, & Jack West consider whether immunotherapy might prove to be more problematic when given to a broader population of older and frail patients with advanced lung cancer.
    • Is It Feasible and Clearly Beneficial to Combine Immunotherapy Approaches? [GRACE :: Lung Cancer]
      Drs. Leora Horn, Ben Solomon, & Jack West review the potential rationale and possible limitations of combining different immuntherapy strategies with one another.
    • Clinical Trial Spotlight: Should a Third Generation EGFR Inhibitor be First Line Therapy for EGFR Mutation-Positive NSCLC? [GRACE :: Lung Cancer]
      Dr. Jack West introduces the question of whether third generation EGFR tyrosine kinase inhibitors osimertinib and rociletinib should be used as first line therapy rather than for acquired resistance, including discussing key clinical trials on the topic.

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