Article and Video CATEGORIES

Cancer Journey

Search By

Dr. Jack West is a medical oncologist and thoracic oncology specialist who is the Founder and previously served as President & CEO, currently a member of the Board of Directors of the Global Resource for Advancing Cancer Education (GRACE)

 

Adjuvant Tarceva for Patients with Resected Early Stage EGFR Mutation-Positive NSCLC: Dr. Neal on the SELECT Trial

Please Note: New Treatments Have Emerged Since this Original Post
Author
Howard (Jack) West, MD

Here is Dr. Neal's summary from the ASCO 2012 Lung Cancer Highlights program of the SELECT Trial, which he led and presented, of adjuvant (post-operative) Tarceva (erlotinib) for patients with resected early stage EGFR mutation-positive NSCLC.   This is a phase II study with only preliminary results, but it demonstrated some important concepts about feasibility and the potential utility of adjuvant Tarceva in this setting.

The video and audio versions of the podcast appear below, along with the transcript and figures.

Dr. Neal ASCO 2012 LC Highlights SELECT Trial Adjuvant Tarceva Audio Podcast

Dr. Neal ASCO 2012 LC Highlights SELECT Trial Adjuvant Tarceva Figs

Dr. Neal ASCO 2012 LC Highlights SELECT Trial Adjuvant Tarceva Transcript

We'll have one more summary piece by Dr. Neal coming up, on the subject of molecular markers being detected for squamous NSCLC, and then close out the podcast series on this program with the question and answer session that followed.  

With regard to the controversial question of whether patients with a detected EGFR mutation should pursue adjuvant Tarceva outside of a clinical trial setting, one lung cancer luminary recently described it as a conflict between your heart and your head.  He noted that while the data aren't there to support it yet, it's understandably tempting.  However, there are also side effect risks to consider for people who might already be cured, and for whom we don't really have an established optimal duration of therapy. Would you want to receive post-operative Tarceva, knowing that it's value isn't clearly defined? Would you favor a fixed duration of treatment or indefinite therapy, understanding that there is a cost in terms of chronic side effects as well as the financial cost of nearly $5000/month? 

Next Previous link

Previous PostNext Post

Related Content

Image
Bladder Cancer Video Library 2024
Video
Dr. Petros Grivas discusses intravesical treatment for patients with nonmuscle invasive, or early-stage, bladder cancer, the importance of participating in clinical trials for bladder cancer, combination therapy options for patients with metastatic or incurable bladder cancer, and the importance of family history of cancer and discussing that history with your doctor.
Image
Case Based Panel
Video
The panel discusses treatment options for a patient diagnosed with EGFR Exon 19 Deletion NSCLC and examines data from the Laura Trial, a patient with a smoking history and diagnosis of small cell lung cancer, and how the Adriatic Study factors into decisions, and a patient with NSCLC adenocarcinoma, and a EGFR Exon 21 L858R Alteration, and how data from the Flaura 2 Trial can impact treatment decisions.
Image
Terapias Dirigidas de Cancer de Pulmón 2024
Video
La Dra. Estelamari Rodríguez presenta información básica sobre el NSCLC EGFR+ y analiza la importancia de las pruebas de biomarcadores en el cáncer de pulmón y ofrece una descripción general de las opciones de tratamiento para la enfermedad EGFR+.  Para ver la playlist completa, de click aquí.        

Forum Discussions

Hello Linda, my name is Alexandra Beneke, I'm the Outreach Manager for GRACE. Your willingness to share your experiences and knowledge with the cancer community is truly inspiring. Your dedication to...

Hi Bluebird,  Welcome to GRACE.  I'm sorry you're going through this scare and hope it's just inflammation or from an infection you didn't know you had. 

 

A CT would be...

Radiation + Brain Operation has just been discarded due to high risk. They will double Tagrisso dosis and then wait to see if it works, then try traditional Chemo. I would...

Hi and welcome to GRACE.  I'm sorry to know you are entering a new stage.  I'm not about to comment just now but wanted to let you know I see your...

Edit to say, we can't give advice but we can comment with views and facts.  :)

 

My first thought is to ask if she has been seen at a large...

Hi Barbro, Welcome to GRACE. I'm sorry you're worrying about this. We aren't able to give feedback on scan reports. Interpreting scan reports in this setting is not only unethical but...

Recent Comments

JOIN THE CONVERSATION
Tagrix FDA Approval
By mariachristian on
Hi Judy! It is so good to…
By JanineT GRACE … on
Tagrix vs Tagrisso
By Dipakchavan on
Hello Linda, my name is…
By AlexandraGBeneke on