New and first time post. Wife diagnosed nsclc 7/2012 stage 4 ALK mutation. Now 57 never smoker and active exerciser. Full 6 treatments carbo/alimta and 1plus year alimta maintenance. Crizotinib about a year forced to ceritinib due to more than 25 brain mets and balnce issues. also at same time, whole brain radiation in 10/2015 mistake??? Brain mets size reduced and stable as of 6/2016. Was it radiation or ceritinib?? Bone mets in shoulder 2/2016 and palliative rad. Bone mets, in hip and spine with doc reading bone scan, 8/2016, believing size increase while our onc believes they are same as last scans. Wife is confused and short term memory loss noticeable along with fast lost of balance and now using walker with quick and long lasting fatigue. Onc doc says nothing to lose by trying alectinib at this point as it may help with bone, spine mets and brain mets which may be cause of balance and leg control. Alectinib to start after brain MRI scheduled for 9/14/2016 to check size of mets to check how alectinib works. Don't want to second guess but maybe no WBR until after use of ceritinib but with more than 25 fear was a factor. I believe she has lasted longer than expectations as mets were already in spine, ribs, adrenals, lymphs and behind retina at initial diagnoses. She has responded well with every treatment but wearing out. I know it could be affects of WBR but fearful of mets in spine causing issues also. Thoughts?? Thanks. Note that up till 10/2015 quality of life pretty good all things considered.
Thu, 09/08/2016 - 16:47#1
4 plus years stage 4 NSCLC with ALK mutation - 1288552