My sister diagnosed to have metatstatic breast cancer on July 2011 which undergoing surgery on Nov 2011, radiation therapy on Dec 2011 and chemotherapy as well as targeted therapy Herceptin for 18 doses with the start of tamoxifen since January this year. She is ER strong positive, PR negative, C-erb B2 equivocal as shown on surgical specimen. Since the disease showed progression with the increasing in bone metatstasis on spine, shoulder and pelvic region in recent PET scan on June 2012 , oncologist suggested her to do ovarian ablation using RT and using another hormonal drug called AI. As I think that Tamoxifen has no benefit to my sister, then is another hormonal drug may help? My another concern is that ovarian ablation may induce some other adverse effect on the body as it may interfere with the hormonal/eco system inside the body. Besides, my sister already got multiple bone metatasis , one of the side effect of AI may induce osteoporosis, then would it make the bone more osteopenic and therefore easier to break. Do you think ovarian ablation is really got beneficial to my sister? What is the gain in survival rate as well as the psychological benefit with the use of it? I know that you may think that I have too much worry but I really want to think of the best way of treatment to my sister and she can maintain her quality of life during her last time. We are very afraid to do as we think that it might not be useful, so we are now just depending on Chinese medicine alone. Besides, I may start using alternative cancer treatment suggested by Budwig center which based on the alternation of diet and have additonal nutritional supplement for the patient. I know that cancer patient may end in a difficult life. My only wish is that sister can maintain her quality of life and we can live under psychological healthiness. Looking forward for your advice on the future management of my sister.
With many thanks for your advice,