Adjuvant therapy for nsclc - 1245393

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augustov
Adjuvant therapy for nsclc - 1245393

Is there any role for adjuvant chemotherapy in resected pure(nonivasive)BAC. Lets say the tumor is 5cm without nodal involvement.

Dr West
Reply To: Adjuvant therapy for nsclc

Tough call. Some might put it in the same category as another resected NSCLC tumor and give it, but noninvasive, pure BAC typically demonstrates a more favorable prognosis that might well be considered too favorable to justify the negative effects of post-operative chemo. There isn't any textbook answer here, and I think this is a case that merits an individual discussion of the potential pros and cons, fitness of the patient for chemo, their level of anxiety about cancer recurrence vs. chemotherapy, confidence that there is NO invasive component, etc. Overall, though, I think most general oncologists and lung cancer specialists would be less inclined to recommend adjuvant chemotherapy for someone with a non-invasive pure BAC than with just about any other lung cancer histology.

-Dr. West

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Dr. Howard (Jack) West
Medical Oncologist
City of Hope Cancer Center
Duarte, CA

Founder & President
Global Resource for Advancing
Cancer Education

augustov
Reply To: Adjuvant therapy for nsclc

Thanks for the information. In this particular case I did not offer any systemic therapy. The way I see this tumor is sort of a dcis of the lung but with potentially more severe consequences.

Dr West
Reply To: Adjuvant therapy for nsclc

Yes, and in fact the terminology is now shifting to BAC being referred to as "adenocarcinoma in situ" to reflect the similarity to ductal carcinoma in situ (DCIS) in the world of breast cancer.

-Dr. West

+++++++++++++++++++++++++
Dr. Howard (Jack) West
Medical Oncologist
City of Hope Cancer Center
Duarte, CA

Founder & President
Global Resource for Advancing
Cancer Education