Any new medical trials after Tagrisso - 1294141

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lamn
Any new medical trials after Tagrisso - 1294141

Hi my mom was diagnosed with Stage 4 NSCLC and has spread to the bone and brain back in February. Now her doctor giving her Tagrisso and recommend to check the tumor again after taking Tagrisso for another month. I just wondering if there are any clinical trial for her to try after Tagrisso didn't work? Also will Tagrisso help with the tumor in her brain and bone? Thank you!

catdander
Hi lamn,

Hi lamn,

I hope your mom does well on tagrisso for a very long time. It's great to say that yes in the FLAURA trial tagrisso demonstrated efficacy in the brain. Most anti cancer treatment do not penetrate the blood brain barrier. Most lung cancer specialists want to give tagrisso first a try to see if it shrinks or eliminates brain mets before having to try radiation. However if the brain met is causing symptoms then radiation may be the better, quicker, and surer choice.

It's difficult to say what the next step should be. For one thing, by the time your mom needs another treatment there may be more options available. Mutations form during treatment and are cancer's way of working around treatments. This is known as acquired resistance and research is working to address these mutations. Your mom may be a good fit for a promising trial drug, if she tests positive for PD-L1 expression immunotherapy would be a choice (those with egfr + don't usually benefit from immunotherapy), and chemotherapy can be very effective and single agents like alimta may have few if any side effects and work for very long time.

Best of luck to your mom,
Janine

lamn
Thank you Janine for your

Thank you Janine for your response. I hope she respond to Tagrisso for a long time, her doctor want to see how Tagrisso affect her tumor before schedule her for radiation therapy. I read that someone from this forum been on Tagrisso for 51 months before their tumor progressing which gives me hope that my mom will respond to Tagrisso for that long. I hope that they will comes up with a new drug or treatment soon so nobody will suffer from this again.

Now I wonder if there is anything my mom or I can do to help with the responding of the drug? She still in good health, working full-time, have a mild coughing, we're trying to make her eat so she doesn't lose weight, but she lost 3 lbs recently. Anything possible will be a great help!

And one last question, how will cyberknife treatment work with stage 4 lung cancer?

Thanks,
Lam

catdander
Lam,

Lam,

If the weight loss of due to the cancer then shrinking the tumor burden should help bring her appetite back. If she needs a little help until then protein meal substitutes can be very helpful, like ensure plus. Small meals/portions are more appetizing when you don't feel like eating. Tastes can change so introducing new options may work. Eat what sounds and looks good is helpful too, like ice cream. Cooking with bacon and bacon grease for those who eat bacon can attract many people to the table. There are also drugs that help some people if weight loss becomes a problem. Keep an eye out for sores/rashes around and in the mouth from tagrisso (though tagrisso seems to have fewer rash issues than tarceva) and treat asap.

Cyberknife/radio surgery is able to focus radiation to only the tumor without damaging healthy tissue so it's given at a higher dose (only 2 or 4 treatments). Cyberknife can be given to brain mets one at a time as needed where wbr can only be given once maybe twice plus wbr causes more damage to healthy brain tissue.

Janine

lamn
Thank you Janine for the

Thank you Janine for the informations, I can't thank you enough. I will see how the medication respond and post here later.

Lam

catdander
Let me add, cyberknife and

Let me add, cyberknife and gamma knife are types of stereotactic radiosurgery. It is being used also in other non brain tumors that are relatively small such as mets arising from acquired resistance. Dr. Weiss explains here, http://cancergrace.org/lung/2016/03/07/gcvl_lu_local_therapy_limited_acq...

lamn
Hi Ms. Janine, I wonder have

Hi Ms. Janine, I wonder have you heard of CAR-T cell therapy for lung cancer? I know that it still in in trial but is there any hope that this method will work for patient with advanced lung cancer? I really appreciate any information available.

Lam

JimC
Hi Lam,

Hi Lam,

So far CAR-T therapy has shown some good results in blood-based cancers such as lymphoma, but though there is some clinical trial work in solid tumors such as lung cancer, it's too soon to say that this therapy will be effective for lung cancer patients.

JimC
Forum moderator

<p>I began visiting GRACE in July, 2008 when my wife Liz was diagnosed with lung cancer, and became a forum moderator in January, 2010. My beloved wife of 30 years passed away Nov. 4, 2011 after battling stage IV lung cancer for 3 years and 4 months</p>