Dr. West, I have been trying to conduct online research about possible treatments to address bronchorrhea. I have mucinous BAC (ALK+) and although I am seven and 1/2 years out from diagnosis, bronchorrhea has been a troublesome side effect only recently. I have had more extensive disease at earlier dates, so it is a bit curious. However, I am slowly developing resistance to my current therapy (LDK378) and the worsening of the bronchorrhea does correlate. I do wonder if my lung tissue may also be less viable than previously (scarring?) and if this may be a contributing factor.
However, what I would really like to know is whether or not there have been any developments in managing this (unpleasant) symptom? The earlier evidence that Iressa was helpful, was that only in patients who were EGFR+? Is your thinking that the best management is still to address the underlying disease? It is a tough call for me, as I would like to stay on my current therapy as long as possible (for all the obvious reasons but also because there are few ill effects on my quality of life).
I know this is an area of interest for you and that it is an uncommon side effect of a less common form of BAC, so I am hoping you might have some insights to offer.