my husband was Dx stage 4 NSCLC, ALK +'ve, 14/12 ago, with initial lesion being only 26 mm but with pleural spread.
With 4 cycles of carbo/alimta/avastin there was shrinkage to 18mm.
there was some further shrinkage with initial maintenance of 3 weekly cycles of Alimta/Avastin then stability at 12 mm for several months, but now with last scan there has continued to be shrinkage, now down to 7mm!
Has there been other such positive response to ongoing Alimta/Avastin maintenance therapy in ALK +'ve pts?
We missed being on the phase 3 Crizotinib trial in Aust, because he had already had first dose of Avastin.
My understanding is that that trial is now finished and all those who were on the Alimta arm, are now on Crizotinib.
Is it the Avastin that has made the difference?
(Note he's also been on Duloxetine for last 6/12, for peripheral neuropathy side effects.)
I appreciate we have to wait for the Alimta/Avastin trial that is ongoing, but I understand early results on breast and bowel cancer seemed not to be so promising.
Maybe it's the power of prayer.
grateful, but a little confused!
fiona and David McDonald